IgA nephropathy

R Coppo, L Peruzzi - Pediatric Kidney Disease, 2023 - Springer
… Sendai virus after induction of defective mucosal tolerance [63, … , favoring the delivery of
nephritogenic IgA. Human B cells … , as detected in experimental models of oral immunization in …

The origin and activities of IgA1-containing immune complexes in IgA nephropathy

B Knoppova, C Reily, N Maillard, DV Rizk… - Frontiers in …, 2016 - frontiersin.org
… The IgA in these renal deposits is galactose-deficient IgA1, … the formation and the nephritogenic
activities of these complexes. … short-term culture experiments of human tissues supported …

Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance.

CO Elson, KW Beagley, AT Sharmanov… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
induction of oral tolerance by feeding the Ag inducing the disease. This has been found in
experimental models of arthritis (15), IgA nephropathy (16… promotes IgG2a synthesis, whereas …

Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?

L Vergano, E Loiacono, R Albera, R Coppo… - Journal of …, 2015 - Springer
nephritogenic IgA are still unknown. Genetic conditioning [10] as well a defective mucosal
toleranceExperimental models suggest a role played by alimentary antigens including gluten […

The microbiome and IgA nephropathy

K Haniuda, JL Gommerman, HN Reich - Seminars in Immunopathology, 2021 - Springer
… the brain following induction of experimental autoimmune … -deficient IgA1 and anti-glycan
IgG, demonstrating that the … , which is triggered by hyperactivation of IgA-promoting cytokines …

T cells in crescentic glomerulonephritis

PG Tipping, SR Holdsworth - Journal of the American Society of …, 2006 - journals.lww.com
… Administration of IL-12 restores initiation of nephritogenic … in induction of tolerance, and in
experimental autoimmune anti-… in the pathogenesis of IgA nephritis, as “circulating IgA-immune …

[HTML][HTML] Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis

SR Holdsworth, AR Kitching, PG Tipping - Kidney international, 1999 - Elsevier
… of experimental and human GN that address the Th1 or Th2 predominance of nephritogenic
… Given the wide spectrum of severity and outcome in IgA nephropathy, it may be simplistic to …

IgA nephropathy—human disease and animal model

Y Endo - Renal failure, 1997 - Taylor & Francis
… used in experimental models of IgA nephropathy discussed in the … : Defective oral tolerance
promotes nephritogenesis in experimental IgA nephropathq induced by oral immunization. f …

Contrasuppression in the mucosal immune system

H Kiyono, DR Green, JR McGhee - Immunologic Research, 1988 - Springer
… This hypothesis was partially supported by an experimentIgA nephropathy following repeated
oral exposure to either bovine … of nephritogenic effector T cells and interstitial nephritis in …

[HTML][HTML] Combined glomerular deposition of polymeric rat IgA and IgG aggravates renal inflammation

MGA Van Dixhoorn, T Sato, Y Muizert… - Kidney international, 2000 - Elsevier
IgA nephropathy (IgAN) is characterized by deposition in the … These mesangial codeposits
may participate in the nephritogenesisExperiments were performed with IgA produced by the …