… hypothesis that defects in the regulation of local IgA response … for the production of
nephritogenic IgA production, and these … activity in experimental IgA nephropathy rats. Am J …

… This has been termed oral tolerance (reviewed in 1). Intranasal im… In preliminary experiments
we determined the optimal in… In a rodent model of IgA nephropathy pharmacologic in…

… Defective antigen clearance and prolonged antigenic … trigger the production of nephritogenic
IgA. RNA from group B … , experimental models of antigen-induced IgA nephropathy have …

… cells in nephritogenic immunity and injury in experimental … was induced in wild-type and
IL-17RA-deficient (IL-17RA -/- ) … SG-immunized IL-17RA -/- mice were relatively TFH deficient…

… IgA antibodies may result in the formation of nephritogenic … and oral tolerance by specifically
interfering with the inhibition of … to the design of the experiments whose description follows. …

… Gesualdo, L., Lamm, ME, Emancipator, SN, Defective oral tolerance promotes nephritogenesis
in experimental IgA nephropathy induced by oral immunization. J Immunol, 1990; 145: …

… IL-13-deficient mice showed higher levels of circulating nephritogenic antibodies with … ’
antigens, probable ‘immune dysregulation’ in IgA nephropathy), our incomplete knowledge of the …

… evidence on its control comes from experimental animals. … with IgAN, arguing against defective
clearance by this route, … the IgA system, resulting in production of IgA with nephritogenic …

… autocrine C3ar1/C5ar1 transduction promotes Teff activation led to the … Although a defect in
DAF in human uveitis has not yet been … The experiments on ocular and oral tolerance yielded …

… of IgA contribute to the development of human IgA nephritis [45]. So far… Inducing NTS nephritis
in interleukin4 deficient mice … S: Th1 responsiveness to nephritogenic antigens determines …