… in more options for developing GA inhibitors into therapeutic agents. Herein, we report a
novel class of thiazolidine-2,4-dione derived glutaminase inhibitors that preferentially inhibit the …

… in the chronological order of discovery, herein we report the representative classes of
BPTES-derived GLS inhibitors in a way that allows readers to appreciate how molecular structures …

… binding site for novel allosteric inhibitors which bind GLS1 at … In summary, this series of
thiazolidine-2,4-dione compounds … a novel backbone for the development of GLS inhibitors. …

… derivatives from 2000 to 2011. In 2013, Jain and coauthors [56] reviewed the multifarious
applications of various thiazolidine-2,4-dione derivatives… -amylase and urease inhibitors. In this …

… 6, (9) UPGL00004, (10) thiazolidine-2,4-dione derivatives, (11) and CB839, (12) as shown
in Figure 1. Thiazolidine-2,4-dione derivatives contain a Michael acceptor and react to KGA …

… for novel antitumor GLS1 inhibitors with higher potency, we designed a series of WA derivatives
… of substituents derived from small molecule GLS1 inhibitors via different linkers (Fig.á2). …

… In this review, recent efforts to develop small molecule glutaminase inhibitors that target
glutamine metabolism in both … Design, synthesis, and evaluation of thiazolidine2,4-dione …

… of the inhibitors in the allosteric pocket (Figure 2b). Inspired by this discovery, we hypothesized
that rationally designed GAC inhibitors would form polar interactions with the P3 hotspot. …

… in vitro and cellular glutaminase-inhibiting activity. In summary, we discovered a new
glutaminase inhibitor with an … (37) A novel class of thiazolidine-2,4-dione-derived glutaminase …

… In summary, a novel series of thiazolidine-2,4-dione derivatives were designed,
synthesized, and evaluated as glutaminase inhibitors in this research. These potent analogues …