… [1, 2, 4] triazolo [4, 3-a] quinoxaline-1-thiol-derived DNA intercalators: design, synthesis, molecular docking, in silico ADMET profiles and anti-proliferative evaluations
… is substituted at position 4 with different moieties, such as ester… of our newly synthesized
VEGFR-2 inhibitors is toxicity. As … been designed, synthesized and evaluated for their anticancer …
VEGFR-2 inhibitors is toxicity. As … been designed, synthesized and evaluated for their anticancer …
… , 2, 4] triazolo)[4, 3-a: 4′, 3′-c] quinazoline derived DNA intercalators: Design, synthesis, in silico ADMET profile, molecular docking and anti-proliferative evaluation …
… active than kinase inhibitors. These compounds … anticancer activity than the other compounds
that containing only one hydrazine moiety linked to the tetracyclic chromophore bis([1,2,4…
that containing only one hydrazine moiety linked to the tetracyclic chromophore bis([1,2,4…
Design, synthesis and cytotoxicity screening of new synthesized pyrimidine-5-carbonitrile derivatives showing marked apoptotic effect
… with the design and synthesis of a hybrid antitumor model of … molecules 5a and 6c revealed
good inhibition of VEGFR-2 … agents bearing diaryl urea functionality as potential inhibitors …
good inhibition of VEGFR-2 … agents bearing diaryl urea functionality as potential inhibitors …
Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations
A Elwan, H Sakr, AGA El-Helby, A El-Morsy… - … of Enzyme Inhibition …, 2022 - Taylor & Francis
… -Topo II inhibitors have been prepared and their anticancer actions … Molecular docking
studies showed that the HBA present in the chromophore, the substituted distal phenyl moiety and …
studies showed that the HBA present in the chromophore, the substituted distal phenyl moiety and …
Design, synthesis, anti-varicella-zoster and antimicrobial activity of (isoxazolidin-3-yl) phosphonate conjugates of N1-functionalised quinazoline-2, 4-diones
M Łysakowska, IE Głowacka, G Andrei, D Schols… - Molecules, 2022 - mdpi.com
… -2,4-dione linked via the N3 atom to the isoxazolidine moiety was synthesized to evaluate the
… The respective N 3 -allyl-N 1 -benzylquinazoline-2,4-diones 24a–d were synthesized from …
… The respective N 3 -allyl-N 1 -benzylquinazoline-2,4-diones 24a–d were synthesized from …
Recent anti‐angiogenic drug discovery efforts to combat cancer
… library of molecules, a potent VEGFR-2 inhibitor named CHMFL-… different set of compounds
with 1-benzylquinazoline-2,4(1H,… anticancer activity on various cancer cell lines (Figure 3J). …
with 1-benzylquinazoline-2,4(1H,… anticancer activity on various cancer cell lines (Figure 3J). …
Advances on quinazoline based congeners for anticancer potential
… The objective of this review manuscript is to evaluate and provide an in-depth insight into …
[1,4]-dioxino quinazoline moiety were prepared and screened as VEGFR-2 inhibitors. Among …
[1,4]-dioxino quinazoline moiety were prepared and screened as VEGFR-2 inhibitors. Among …
Halogenated flavonoid derivatives display antiangiogenic activity
… , synthetic flavones (5a,b) with reported anticancer activity, … Conversely, derivatives with a
4-carbonyl moiety fitted poorly … flavone derivatives bearing a C=O group at position number 4 (…
4-carbonyl moiety fitted poorly … flavone derivatives bearing a C=O group at position number 4 (…
Design and synthesis of a new series of hybrids of functionalised N1-[(1H-1, 2, 3-triazol-4-yl) methyl] quinazoline-2, 4-dione with antiviral activity against Respiratory …
IE Głowacka, K Gawron, DG Piotrowska, M Graus… - Antiviral Research, 2023 - Elsevier
… Various synthesised compounds bearing the quinazoline-2,4-dione moiety exert a broad
range of biological activities. … On the other hand, N 1 -benzylquinazoline-2,4-diones 6 having …
range of biological activities. … On the other hand, N 1 -benzylquinazoline-2,4-diones 6 having …
Synthesis of 3-(Pyridin-2-yl)quinazolin-2,4(1H,3H)-diones via Annulation of Anthranilic Esters with N-pyridyl Ureas
SO Baykova, KK Geyl, SV Baykov… - … Journal of Molecular …, 2023 - mdpi.com
… -2,4-dione derivatives were recognized as inhibitors of … XII [19], histone deacetylase-6 [20],
VEGFR-2 [21], tankyrases [22], … , using ureas bearing quinoline and isoquinoline moieties 1l–…
VEGFR-2 [21], tankyrases [22], … , using ureas bearing quinoline and isoquinoline moieties 1l–…