… poly(ADP-ribose) polymerase (PARP), a recently discovered fundamental mechanism in
the pathogenesis of diabetes complications including endothelial dysfunction… diabetes-induced …

… vasodilatation also manifests in improvements in other functions of the FIGURE 14.5
Reversal of diabetes-induced endothelial dysfunction by pharmacological inhibition of PARP. …

… the diabetes-induced death of retinal capillary cells. PARP inhibition prevented both the
hyperglycemia-induced death of retinal endothelial cells and the diabetes-induced increase in …

… poly(ADP-ribose)polymerase (Parp) activity and assess whether and how a Parp inhibitor,
nicotinamide (NAm), may potentially regulate the diabetes-induced … in diabetes-induced brain …

Poly(ADP-ribose) polymerase (PARP) comprise of a family of enzymes which catalyses poly(ADPribosyl)
ation of DNA-binding proteins. To date, seven isoforms have been identified: …

… From these observations, we concluded that PARP inhibition counteracts diabetes-induced
changes in nerve energy state (the variable that correlates best with nerve conduction) …

… ameliorated diabetes-induced albumin excretion and mesangial expansion, which are
hallmarks of diabetic nephropathy. PARP inhibitors decreased diabetes-induced podocyte …

… Although specific inhibitors of individual pathways each ameliorate or prevent various
diabetes-induced functional and structural abnormalities in cell culture and animal models, there …

… Two different but complimentary models of chronic diabetic complications were used to
determine the role of PARP in the development of diabetes-induced diseases in the retina, kidney…

… Diabetes-induced increase in peripheral nerve nitrotyrosine immunoreactivity, epineurial
vessel superoxide and nitrotyrosine immunoreactivities, and aortic superoxide production was …