… to overactivation of poly (ADP-ribose) polymerase (PARP). In … as a PARP inhibitor) in
diabetes-induced neurobehavioral and … Cerebrovascular changes like reduced blood flow to the …

Poly (ADP-ribose) polymerase-1 (PARP-1) functions at the center of cellular stress and
sways the immune system at several key points, thus modulates inflammatory diseases. The …

… activation of an abundant nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP). This …
oxide (NO; endothelial dysfunction) and also leads to a severe functional impairment of the …

… (b) Following ethanol exposure PARP is activated and adds Poly ADP Ribose (PAR)
groups to Pγ. (c) The addition of PAR groups to Pγ prevents it from binding its targets. (For …

… breakage is activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP). PARP
activation is involved in early diabetes-induced nerve blood flow reduction, nerve conduction …

… induces DNA strand breaks activating poly (ADP-ribose) polymerase (PARP). … cerebral
vessels in animals) [15]. Another PKC mediated mechanism that enhances vascular dysfunction …

… by nitrotyrosine and poly(ADP-ribose) accumulation (… dysfunction and degeneration
remain unknown. Here, we provide the first evidence of the key role of iNOS in diabetes-induced …

… PARP-1 and poly(ADP-ribose) antibodies were obtained from … in both poly(ADP-ribose)
immunofluorescence and poly-(ADP-… Diabetes-induced PARP activation has been shown to be …

… This study shows for the first time the role of poly(ADP-ribose) … inhibitor, in transient
focal cerebral ischemia in mice. Br J … Diabetesinduced overexpression of endothelin-1 and …

… overcome diabetes-induced vascular dysfunction. Diabetes-induced vascular dysfunction is
… It has been reported that NF-κB subunits interact with poly(ADP-ribose) polymerase (PARP)-…