The role of human dopamine transporter in NeuroAIDS

J Zhu, S Ananthan, CG Zhan - Pharmacology & therapeutics, 2018 - Elsevier
Attenuating inhibitory effects of Tat and cocaine on DA transport are important for preventing
directly targeting the specific binding sites on hDAT for Tat could provide a viable …

Major coexpression of κ‐opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles

AL Svingos, C Chavkin, EEO Colago, VM Pickel - Synapse, 2001 - Wiley Online Library
… Dual actions on dopamine terminals and their targets in the Acb may … effect of KOR
activation is exemplified by attenuation of cocaine- and heroin-induced increases in extracellular

… , a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 …

J Zhu, PM Quizon, Y Wang, CA Adeniran, MJ Strauss… - …, 2022 - Elsevier
… levels such as the type achieved by allosteric targeting of dopamine transporter activity. …
effects on behavior. The normalization of dopamine uptake and extracellular dopamine levels …

Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse

KC Schmitt, MEA Reith - Annals of the New York Academy of …, 2010 - Wiley Online Library
… show an attenuated response to cocaine and amphetamines … agonists attenuate the dramatic
rise in extracellular dopamine … as potential targets for novel cocaine addiction therapeutics. …

Rapid regulation of the dopamine transporter: role in stimulant addiction?

NR Zahniser, A Sorkin - Neuropharmacology, 2004 - Elsevier
… Likewise, lesion of mesocorticolimbic DA neurons attenuates … this approach, we again
found that the initial dose of cocaine … to use a direct method to confirm basal/cocaine-induced …

Effects of pharmacologic increases in brain GABA levels on cocaine‐induced changes in extracellular dopamine

AE Morgan, SL Dewey - Synapse, 1998 - Wiley Online Library
attenuating the effect of cocaine on NACC DA. Taken with our earlier findings, these results
support the targeting … the utility of GVG to attenuate cocaine-induced changes in extracellular …

[HTML][HTML] Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter

WL Sun, PM Quizon, Y Yuan, W Zhang, S Ananthan… - Scientific reports, 2017 - nature.com
Dopamine transporter (DAT) is the target of cocaine and HIV-1 … effect of cocaine on DA
uptake and attenuate the effects of … to the extracellular region where it interacts directly with Tat …

Agents in development for the management of cocaine abuse

DA Gorelick, EL Gardner, ZX Xi - Drugs, 2004 - Springer
… lesions of the nucleus accumbens attenuate the rewarding effects of intravenous cocaine; (vii)
… presents a possible target for indirectly modulating dopaminergic brain substrates relating …

Sigma1 (σ1) receptor antagonists represent a new strategy against cocaine addiction and toxicity

T Maurice, R Martin-Fardon, P Romieu… - Neuroscience & …, 2002 - Elsevier
… in the activation of numerous particular targets. Among them, … is involved in a direct modulation
of intracellular calcium ([Ca 2… ) attenuate the priming effect of cocaine in rats on a model of …

Interaction of cocaine‐, benztropine‐, and GBR12909‐like compounds with wild‐type and mutant human dopamine transporters: molecular features that differentially …

KC Schmitt, J Zhen, P Kharkar, M Mishra… - Journal of …, 2008 - Wiley Online Library
… Neuronal monoamine transporters are targeted by a myriad of … -out mice show an
attenuated response to cocaine and a … approach the transporter from an intracellular trajectory, …