[HTML][HTML] The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors

KC Schmitt, MEA Reith - PloS one, 2011 - journals.plos.org
… chief molecular target of modafinil is the dopamine transporter (… Modafinil attenuates craving
for cocaine during drug … modeling cocaine and phenyltropane binding in the extracellular

Probes for the dopamine transporter: New leads toward a cocaine‐abuse therapeutic—A focus on analogues of benztropine and rimcazole

AH Newman, S Kulkarni - Medicinal research reviews, 2002 - Wiley Online Library
… and excessive accumulation of extracellular dopamine in the … that this molecular target plays
in the reinforcing effects of cocaine. … to attenuate locomotor and rewarding effects of cocaine.…

A novel strategy for the treatment of cocaine addiction

SL Dewey, AE Morgan, CR Ashby Jr, B Horan… - Synapse, 1998 - Wiley Online Library
… GVG significantly attenuated cocaine-induced increases in … For example, cocaineinduced
increases in extracellular DA … is to directly target the DAT with a high-affinity cocaine analog…

[HTML][HTML] Cocaine potency at the dopamine transporter tracks discrete motivational states during cocaine self-administration

CA Siciliano, SR Jones - Neuropsychopharmacology, 2017 - nature.com
… for cocaine is determined by other targets or mechanisms. Finally, we outline a novel approach
for relating drug–targetCocaine-induced increases in extracellular dopamine levels, and …

Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter

M Thomsen, DD Han, HH Gu, SB Caine - Journal of Pharmacology and …, 2009 - ASPET
… The dopamine transporter (DAT) is suspected as the primary target mediating cocaine's
abuse-related effects … failed to increase extracellular dopamine in the nucleus accumbens, or to …

The top 20 dopamine transporter mutants: structure–function relationships and cocaine actions

GR Uhl, Z Lin - European journal of pharmacology, 2003 - Elsevier
transport of dopamine from intracellular to extracellular … of value for targeting dopamine-sparing
cocaine antagonists. The … mutations attenuate cocaine-analog affinities with selectivity. …

Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction

RB Rothman, MH Baumann, TE Prisinzano… - Biochemical …, 2008 - Elsevier
dopamine transporter has historically been a primary target … Importantly, some of these
compounds attenuate cocaine-… uniformly affect cocaine-induced extracellular dopamine increases …

Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants

J Drago, P Padungchaichot, D Accili… - Developmental …, 1998 - karger.com
Cocaine has been shown to inhibit dopamine reuptake by … Preferential labeling of D3Rs
was achieved by attenuating the … on motor behavior and extracellular dopamine in the ventral …

The dopamine transporter and cocaine medication development: drug self-administration in nonhuman primates

LL Howell, KM Wilcox - Journal of Pharmacology and Experimental …, 2001 - ASPET
… that target the dopamine transporter represents a reasonable … can attenuate the
behavioral-stimulant and reinforcing effects of … -state elevations in extracellular dopamine induced …

Role of serotonin in cocaine effects in mice with reduced dopamine transporter function

Y Mateo, EA Budygin, CE John… - Proceedings of the …, 2004 - National Acad Sciences
dopamine system originates, is a target of cocaine action. … placed in the NAc on extracellular
dopamine. Other authors (… serotonin activity may attenuate the reinforcing effects of this drug …