[HTML][HTML] The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors
KC Schmitt, MEA Reith - PloS one, 2011 - journals.plos.org
… chief molecular target of modafinil is the dopamine transporter (… Modafinil attenuates craving
for cocaine during drug … modeling cocaine and phenyltropane binding in the extracellular …
for cocaine during drug … modeling cocaine and phenyltropane binding in the extracellular …
Probes for the dopamine transporter: New leads toward a cocaine‐abuse therapeutic—A focus on analogues of benztropine and rimcazole
AH Newman, S Kulkarni - Medicinal research reviews, 2002 - Wiley Online Library
… and excessive accumulation of extracellular dopamine in the … that this molecular target plays
in the reinforcing effects of cocaine. … to attenuate locomotor and rewarding effects of cocaine.…
in the reinforcing effects of cocaine. … to attenuate locomotor and rewarding effects of cocaine.…
A novel strategy for the treatment of cocaine addiction
SL Dewey, AE Morgan, CR Ashby Jr, B Horan… - Synapse, 1998 - Wiley Online Library
… GVG significantly attenuated cocaine-induced increases in … For example, cocaineinduced
increases in extracellular DA … is to directly target the DAT with a high-affinity cocaine analog…
increases in extracellular DA … is to directly target the DAT with a high-affinity cocaine analog…
[HTML][HTML] Cocaine potency at the dopamine transporter tracks discrete motivational states during cocaine self-administration
CA Siciliano, SR Jones - Neuropsychopharmacology, 2017 - nature.com
… for cocaine is determined by other targets or mechanisms. Finally, we outline a novel approach
for relating drug–target … Cocaine-induced increases in extracellular dopamine levels, and …
for relating drug–target … Cocaine-induced increases in extracellular dopamine levels, and …
Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter
… The dopamine transporter (DAT) is suspected as the primary target mediating cocaine's
abuse-related effects … failed to increase extracellular dopamine in the nucleus accumbens, or to …
abuse-related effects … failed to increase extracellular dopamine in the nucleus accumbens, or to …
The top 20 dopamine transporter mutants: structure–function relationships and cocaine actions
GR Uhl, Z Lin - European journal of pharmacology, 2003 - Elsevier
… transport of dopamine from intracellular to extracellular … of value for targeting dopamine-sparing
cocaine antagonists. The … mutations attenuate cocaine-analog affinities with selectivity. …
cocaine antagonists. The … mutations attenuate cocaine-analog affinities with selectivity. …
Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction
… dopamine transporter has historically been a primary target … Importantly, some of these
compounds attenuate cocaine-… uniformly affect cocaine-induced extracellular dopamine increases …
compounds attenuate cocaine-… uniformly affect cocaine-induced extracellular dopamine increases …
Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants
J Drago, P Padungchaichot, D Accili… - Developmental …, 1998 - karger.com
… Cocaine has been shown to inhibit dopamine reuptake by … Preferential labeling of D3Rs
was achieved by attenuating the … on motor behavior and extracellular dopamine in the ventral …
was achieved by attenuating the … on motor behavior and extracellular dopamine in the ventral …
The dopamine transporter and cocaine medication development: drug self-administration in nonhuman primates
LL Howell, KM Wilcox - Journal of Pharmacology and Experimental …, 2001 - ASPET
… that target the dopamine transporter represents a reasonable … can attenuate the
behavioral-stimulant and reinforcing effects of … -state elevations in extracellular dopamine induced …
behavioral-stimulant and reinforcing effects of … -state elevations in extracellular dopamine induced …
Role of serotonin in cocaine effects in mice with reduced dopamine transporter function
Y Mateo, EA Budygin, CE John… - Proceedings of the …, 2004 - National Acad Sciences
… dopamine system originates, is a target of cocaine action. … placed in the NAc on extracellular
dopamine. Other authors (… serotonin activity may attenuate the reinforcing effects of this drug …
dopamine. Other authors (… serotonin activity may attenuate the reinforcing effects of this drug …