… -1R targeted pharmacotherapies remain a promising approach … samples fluctuations in
extracellular dopamine over minutes, … to attenuate components of this signaling in the presence of …

… DAT in dopamine nerve terminals suggesting an additional target by which … released into
the extracellular space and the activity of DAT … In addition, KOR agonists attenuate cocaine self-…

… , dopamine can have completely opposing effects on target … reuptake of extracellular
dopamine into the intracellular space. … -mediated DAT internalization is blocked by cocaine which …

… that increases extracellular dopamine levels by targeting the dopamine transporter (DAT) and
… reported that σR ligands attenuate some of the behavioral effects of cocaine and METH in …

… D 1 dopamine receptor and intracellular signaling mediated … will discuss how targeting
the D 1 dopamine receptor and its … an attenuated locomotor response to repeated cocaine …

… dopamine transporter is a key target or “receptor” for cocaine … the cocaine-induced increase
in extracellular dopamine in the … pharmacokinetic approaches to attenuating cocaine action …

… altered dopamine transport kinetics and increased cocaine-… TM4-9 hub a new target for
pharmacological modulation of DAT … reuptake of dopamine from the extracellular space. The …

… -effects of cocaine [60] and potentiated cocaine’s effects on DA … consistent attenuation of a
wide range of effects of cocaine by … in extracellular DA levels was slower than that for cocaine. …

… and attenuated response to amphetamine. In cultured … , we first substitute the PDZ-target
sequence (–LLV) with alanine … our recently developed fluorescent cocaine analogue, JHC 1–64…

… to normalize elevated basal extracellular dopamine. These … may provide important therapeutic
targets for the development … 3 R deletion attenuates the NAc DA response to cocaine. We …