Mutations at tyrosine 88, lysine 92 and tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport
… and provide mechanistic insights into identifying target residues on the DAT for Tat binding.
… The psychostimulant action of cocaine is mediated by increased extracellular DA in the brain…
… The psychostimulant action of cocaine is mediated by increased extracellular DA in the brain…
Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice
TA Perles-Barbacaru, D Procissi, AV Demyanenko… - Neuroimage, 2011 - Elsevier
… of abuse target plasma membrane reuptake transporters for … response to cocaine in these
regions was attenuated but not … reinforcing effects of cocaine in DAT KO mice at the cocaine …
regions was attenuated but not … reinforcing effects of cocaine in DAT KO mice at the cocaine …
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors
C De Mei, M Ramos, C Iitaka, E Borrelli - Current opinion in pharmacology, 2009 - Elsevier
… dopaminergic neurons, but also on neurons targeted by … release in conditions of high
extracellular DA levels might explain … of motor activity by cocaine is greatly attenuated in D2R−/− …
extracellular DA levels might explain … of motor activity by cocaine is greatly attenuated in D2R−/− …
PET imaging of dopamine transporters and D2/D3 receptors in female monkeys: effects of chronic cocaine self-administration
MI Allen, AN Duke, SH Nader, A Adler-Neal… - …, 2023 - nature.com
… Cocaine is a monoamine transport blocker, elevating extracellular concentrations of brain
dopamine … how long-term cocaine exposure on DAT function can be used as a target for novel …
dopamine … how long-term cocaine exposure on DAT function can be used as a target for novel …
Membrane trafficking regulates the activity of the human dopamine transporter
HE Melikian, KM Buckley - Journal of Neuroscience, 1999 - Soc Neuroscience
… and intracellular trafficking of the cocaine- and amphetamine-sensitive dopamine transporter
(DAT)… Although DAT activity is significantly attenuated by exogenously administered agents, …
(DAT)… Although DAT activity is significantly attenuated by exogenously administered agents, …
Visualization of the cocaine-sensitive dopamine transporter with ligand-conjugated quantum dots
… and is a major target for the psychostimulants cocaine and … Cocaine is a competitive DAT
inhibitor and attenuates DA … an extracellular epitope does not allow direct localization and …
inhibitor and attenuates DA … an extracellular epitope does not allow direct localization and …
Tamoxifen directly interacts with the dopamine transporter
SR Mikelman, B Guptaroy, KC Schmitt, KT Jones… - … of Pharmacology and …, 2018 - ASPET
… tamoxifen increases extracellular dopamine in vivo and acts … in a cocaine-like manner and
does not affect surface expression … that tamoxifen attenuates both [ 3 H]dopamine uptake and …
does not affect surface expression … that tamoxifen attenuates both [ 3 H]dopamine uptake and …
Association of stimulant use with dopaminergic alterations in users of cocaine, amphetamine, or methamphetamine: a systematic review and meta-analysis
… known to increase extracellular dopamine levels either by blocking (cocaine) or … dopamine
transporter availability, and the random-effects model we used allows for variations in effects. …
transporter availability, and the random-effects model we used allows for variations in effects. …
Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout
… the dopamine transporter (SL6A3; DAT) display increased locomotion that can be attenuated,
… We show here that the effects of DAT deletion on basal and cocaine-induced locomotion …
… We show here that the effects of DAT deletion on basal and cocaine-induced locomotion …
Novel approaches to the treatment of cocaine addiction
M Sofuoglu, TR Kosten - CNS drugs, 2005 - Springer
… the emerging targets for cocaine pharmacotherapy including … [10,11]Cocaine increases
extracellular dopamine levels by … adrogolide attenuated some of the subjective effects of cocaine …
extracellular dopamine levels by … adrogolide attenuated some of the subjective effects of cocaine …