… in risk assessment in order to extrapolate animal dermal … , skin penetration data are not
used in risk assessment with … percutaneous absorption cannot properly be assessed in 2D-…

… , protecting the body from toxic substances and pathogens. … animal skin models provide,
many different animal models … affect percutaneous absorption and permeation), hairless rat …

… Student's t-test was used to analyse differences between two normally distributed groups. …
the percentage dose penetration in an ex vivo isolated perfused porcine skin flap model at a …

… In vitro and animal models provide important tools for screen… Significant differences in
discriminating power between the … freshly excised) as percutaneous penetration occurs by passive …

… Thus, evaluation of percutaneous penetration of the drug … compartment between which the
animal model membrane is … activity or other factors, such as perfusion differences. Thus, it …

… as models for the prediction of percutaneous penetration in … there are marked differences in
absorption between rat and … Hence the rat model appears to overestimate systemic exposure …

… skin so that studies in percutaneous penetration, metabolism, … regional differences in
percutaneous absorption between body … of in vitro or in vivo animal models. Most agree that in vivo …

… Another inconsistency between articles includes use of … Several factors that might affect
percutaneous penetration, and … solutions, animal models, washing techniques and analysis of …

… In vitro skin penetration data of 12 chemicals was used to … and safety risk assessment using
non-animal approaches is to … For α-hexylcinnamic aldehyde, the predicted errors mainly …

… modelling percutaneous penetration for steady-state models. … to optimise penetration and
to extenuate differences between … Therefore, the issue of assessing percutaneous penetration …