[HTML][HTML] Engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for RET receptor-mediated cell survival

TK Lundgren, RP Scott, M Smith, T Pawson… - Journal of biological …, 2006 - ASBMB
… recruit a number of different docking proteins through the … This difference in biological
outcome supports the idea that … 1 mm glutamine, whereas the neuroblastoma cell line SK-N-MC …

[HTML][HTML] The Shc family protein adaptor, Rai, negatively regulates T cell antigen receptor signaling by inhibiting ZAP-70 recruitment and activation

M Ferro, MT Savino, B Ortensi, F Finetti, L Genovese… - PLoS …, 2011 - journals.plos.org
… Rai/ShcC is a member of the Shc family of protein adaptors … As neuronal progenitors
differentiate ShcA is progressively … different cell types is intriguing but not unique. A similar dual …

The amyloid precursor protein and its network of interacting proteins: physiological and pathological implications

C Russo, V Venezia, E Repetto, M Nizzari… - Brain Research …, 2005 - Elsevier
protein Grb2 both in human brain and in neuroblastoma … APP for the induction of different
cellular pathways. This has … ShcC, which is co-precipitated with CTFs in human brain, as …

[HTML][HTML] A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma

V Mlakar, E Morel, SJ Mlakar, M Ansari… - Journal of Experimental …, 2021 - Springer
… of its deregulation in neuroblastoma, and current promising therapeutics targeting … cell
function as one of the central signaling axes that affect many different cellular functions (…

RAI (ShcC/N-Shc)-dependent recruitment of GAB1 to RET oncoproteins potentiates PI3-K signalling in thyroid tumors

V De Falco, V Guarino, L Malorni, AM Cirafici, F Troglio… - Oncogene, 2005 - nature.com
… to several different proteins with similar functions. The CH1 … of neuronal survival and
differentiation, kidney development, … found in a large set of neuroblastoma cell lines. In these cells …

[图书][B] Regulation of IGF-1 receptor signaling by autophagy in human neuroblastoma cell lines

M Soori - 2014 - search.proquest.com
… risk neuroblastoma remains high, in some cases the disease displays a strikingly unique
In one cascade Shc docking proteins are recruited to the activated receptor (not shown) that …

The Identification of Novel Binding Partners of the Neuronal Adaptor Protein ShcC

RI Grant - 2009 - ir.lib.uwo.ca
… In Neuroblastoma NB-39-nu cells, a distinct function for the … 2) To differentiate the interaction
profiles of the ShcC PTB and … as docking sites for other proteins, and specifically the ShcC

RET and neuroendocrine tumors

M Ichihara, Y Murakumo, M Takahashi - Cancer letters, 2004 - Elsevier
… Growth, differentiation and functions of neuroendocrine cells are controlled by a variety of …
turned out to be the binding site of at least five different docking proteins, SHC, FRS2, DOK4/5 (…

[HTML][HTML] Positive association of human SHC3 gene with schizophrenia in a Northeast Chinese Han population

Y Lv, Y Sun, GY Wang, J Yin, CJ Li, YY Luo… - Psychiatry …, 2020 - ncbi.nlm.nih.gov
… transforming protein 3 (SHC3), also known as N-Shc, ShcC … of cancer, including aggressive
neuroblastomas and human … different genetic models, and one of them showed difference

[PDF][PDF] Cathepsin Inhibition Prevents Autophagic Protein Turnover and Down-Regulates IGF-1 Receptor Mediated Signaling in Neuroblastoma

M Soori, G Lu, RW Mason - Journal of Pharmacology and …, 2015 - researchgate.net
… causes cell death in neuroblastoma by dysregulation of cell … Specifically, we examine the
role of cathepsins in regulation … ) Distinct role of ShcC docking protein in the differentiation of …