Genetics of schizophrenia

I Escudero, M Johnstone - Current psychiatry reports, 2014 - Springer
… These candidate genes converge on key neuronal signalling … these variants led to the
establishment of different consortia, … this genetic variant brings about the structural and functional

What genes are differentially expressed in individuals with schizophrenia? A systematic review

AK Merikangas, M Shelly, A Knighton, N Kotler… - Molecular …, 2022 - nature.com
… Gaining insight into the mechanistic influences of these genetic variants … and rare genetic
variants, as well as diverse environmental … with specific classes of loss-of-function variants [27]. …

Genomics, convergent neuroscience and progress in understanding autism spectrum disorder

HR Willsey, AJ Willsey, B Wang… - Nature Reviews …, 2022 - nature.com
… , or intersection, of diverse ASD genetic risks with respect to … for rare damaging variants
(case–control, schizophrenia only)… of ultra-rare genetic variation, the characterization of …

Cortical cellular diversity and development in schizophrenia

AJ Price, AE Jaffe, DR Weinberger - Molecular psychiatry, 2021 - nature.com
… to conducting cell type-specific functional genomic studies in … risk attributed to common
genetic variation. For instance, an … of schizophrenia to improve and converge at the cellular level. …

The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology

OB Smeland, O Frei, AM Dale… - Nature Reviews …, 2020 - nature.com
… , many individuals with schizophrenia endure poor societal functioning, stigma and a poor
… and rare genetic variants that implicate various biological pathways in schizophrenia. We …

Copy number variation in schizophrenia in Sweden

JP Szatkiewicz, C O'Dushlaine, G Chen… - Molecular …, 2014 - nature.com
… of genes intersected by rare CNVs implicated functional … This convergence from different
methodologies minimizes risk … We hypothesized that different types of genetic variation can …

Genes and environments in schizophrenia: the different pieces of a manifold puzzle

JM Réthelyi, J Benkovits, I Bitter - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
… how the different forms of genetic variation interact and how … is how genetic and
environmental effects converge on … genetic variability at a specific functional polymorphism of a …

Rethinking the first episode of schizophrenia: identifying convergent mechanisms during development and moving toward prediction

JK Forsyth, CE Bearden - American Journal of Psychiatry, 2023 - Am Psychiatric Assoc
… which genetic variants associated with schizophrenia increase risk… to maximize psychosis
prediction under different contexts. … and functional brain changes in first episode psychosis and …

The genomics of schizophrenia: update and implications

P Giusti-Rodríguez, PF Sullivan - The Journal of clinical …, 2013 - Am Soc Clin Investig
… and genetic epidemiological studies have converged on the … data, the genetic architecture
of schizophrenia is diverse and … the genetic variants that increase risk for schizophrenia differ …

Evaluating historical candidate genes for schizophrenia

MS Farrell, T Werge, P Sklar, MJ Owen, RA Ophoff… - Molecular …, 2015 - nature.com
… , we assumed that genetic variants act on the gene it was in … converging on the null. This is
important because the candidate … Best practices in 2014 are thus very different from 2004. For …