Molecular network analysis enhances understanding of the biology of mental disorders

KS Grennan, C Chen, ES Gershon, C Liu - Bioessays, 2014 - Wiley Online Library
… been identified as a schizophrenia (SZ) risk gene because a … type of data, and converging
evidence from two or more data … in which one locus, genetic variant or gene, affects multiple …

Evaluating historical candidate genes for schizophrenia

MS Farrell, T Werge, P Sklar, MJ Owen, RA Ophoff… - Molecular …, 2015 - nature.com
… , we assumed that genetic variants act on the gene it was in … converging on the null. This is
important because the candidate … Best practices in 2014 are thus very different from 2004. For …

Identification of blood biomarkers for psychosis using convergent functional genomics

SM Kurian, H Le-Niculescu, SD Patel, D Bertram… - Molecular …, 2011 - nature.com
… state that has been the primary goal of the work reported in this paper, regardless of the
proximal causes, which could be diverse and will need to be the subject of subsequent …

De novo mutations in schizophrenia implicate synaptic networks

M Fromer, AJ Pocklington, DH Kavanagh, HJ Williams… - Nature, 2014 - nature.com
… to a major role for transmitted genetic variants 1 . However, it is … Proteins belonging to various
functional sets are as marked, … in schizophrenia, we demonstrate a convergence of de novo …

Schizophrenia as a disorder of molecular pathways

S Horváth, K Mirnics - Biological psychiatry, 2015 - Elsevier
… more varied than the symptomatic diversity of schizophrenia. … to understand the function of
hundreds of genes and regulatory … , schizophrenia can be considered a disease of converging

Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders

EM Kenny, P Cormican, S Furlong, E Heron… - Molecular …, 2014 - nature.com
… of these variants in specific gene networks and intermediate … mutations at a significantly
different rate in cases compared … rare variants, we add further support to the convergent evidence …

[HTML][HTML] Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk

KM Anderson, MA Collins, R Chin, T Ge… - Nature …, 2020 - nature.com
Converging animal and human work provides evidence for … by which cellular diversity
influences brain function is a long-… To determine whether interneuron-related genetic variation is …

Genetic insights into the neurodevelopmental origins of schizophrenia

R Birnbaum, DR Weinberger - Nature Reviews Neuroscience, 2017 - nature.com
… The diverse and protean effects of genetic and epigenetic … — perhaps thousands of —
genetic variants that are common in … The present article focuses on this emerging convergence, …

The road to precision psychiatry: translating genetics into disease mechanisms

MJ Gandal, V Leppa, H Won, NN Parikshak… - Nature …, 2016 - nature.com
… interpretation of genetic variation, focusing on rare variants of … , genetic variants conferring
risk for schizophrenia so far … In ASD, for example, inherited variants converge largely on …

Schizophrenia at a genetics crossroads: where to now?

A Corvin - Schizophrenia bulletin, 2013 - academic.oup.com
… <5% of the total genetic variance in schizophrenia susceptibility (… convergence with known
autism risk genes and genetic … risk variants in gene networks, where loss-of-function mutations …