Dopa inhibits induced proliferative activity of murine and human lymphocytes.

A Slominski, GG Goodman-Snitkoff - Anticancer research, 1992 - europepmc.org
murine splenocytes and human lymphocytes, having little or no effect on unstimulated (control)
lymphocytes or proliferatinginhibit the host's immune response via the release of DOPA

Effect of dopamine on immune cell proliferation in mice

CW Tsao, YS Lin, JT Cheng - Life sciences, 1997 - Elsevier
… percentage inhibition of SKF38393 (low8 M)-induced action … L-DOPA, dopamine and
norepinephrine ( 1 OS5 - 10m4 M) suppressed lymphocyte proliferation and differentiation induced

Physiological concentrations of dopamine inhibit the proliferation and cytotoxicity of human CD4+ and CD8+ T cells in vitro: a receptor-mediated mechanism

B Saha, AC Mondal, J Majumder, S Basu… - …, 2001 - karger.com
… DA-mediated inhibition of lymphocyte proliferation was due to … [3H]dopamine to human
lymphocytes: Possible relationship … : Effect of dopamine on immune cell proliferation in mice. Life …

Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis

E Josefsson, J Bergquist, R Ekman, A Tarkowski - Immunology, 1996 - Wiley Online Library
proliferative responses of spleen mononuclear cells to both Con A and LPS were dosedependently
inhibited by the catecholamines and L-DOPA … study using human lymphocytes.Finally…

In vivo administration of l-dopa or dopamine decreases the number of splenic IFNγ-producing cells

L Carr, A Tucker, R Fernandez-Botran - Journal of neuroimmunology, 2003 - Elsevier
… with l-dopa and dopamine on murine lymphocyte proliferation and … -4-producing cells was
significantly inhibited by l-dopa. This effect … receptors on both murine and human lymphocytes. …

The enhancement of T cell proliferation by L-dopa is mediated peripherally and does not involve interleukin-2

L Carr, A Tucker, R Fernandez-Botran - Journal of neuroimmunology, 2003 - Elsevier
… , l-dopa, for 5 days to BALB/c mice significantly increased Concanavalin A (ConA)-induced
proliferation of lymphocytes. … synthesis inhibitor, suggesting a peripheral action of dopamine. l-…

Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells

A Slominski, B Zbytek… - International journal of …, 2009 - Wiley Online Library
… We assessed L-DOPA effect on lymphocyte proliferation and production of inflammatory …
agreement with our previous findings on L-DOPA effects on murine splenocytes and human

Inhibition of immune cell proliferation with haloperidol and relationship of tyrosine hydroxylase expression to immune cell growth

CW Tsao, YS Lin, JT Cheng - Life sciences, 1998 - Elsevier
… was also inhibited by cycloheximide and … human and mouse lymphocytes (10,ll). Dopamine
production was blocked by AMPT, and increased by incubation with the predursor L-DOPA

Differential Effect of Mixed D1/D2 and Selective D2 Dopaminergic Antagonists on Mouse T and B Lymphocyte Proliferation and Interleukin Production In Vitro

W Boukhris, E Kouassi, JP Revillard - Immunopharmacology and …, 1988 - Taylor & Francis
… flupentixol inhibit the in vitro proliferation of mouse spleen lymphocytes … of mixed D1/D2
dopaminergic antagonists. However, the … -stimulated human lymphocyte proliferation by some …

Dopamine receptors on human T-and B-lymphocytes

L Santambrogio, M Lipartiti, A Bruni… - Journal of …, 1993 - Elsevier
… D2-DA-R on murine and human lymphocytes and thymocytes. … known to inhibit adenylate
cyclase activity through receptor … to levodopa or antipsychotic treatments in these pathologies. …