[HTML][HTML] A2AR transmembrane 2 peptide administration disrupts the A2AR-A2AR homoreceptor but not the A2AR-D2R heteroreceptor complex: Lack of actions on …

DO Borroto-Escuela, K Wydra… - International Journal of …, 2019 - mdpi.com
… administration into the nucleus accumbens enhances … of receptor heteromerization. Direct
epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors

[图书][B] Pharmacological implications of adenosine 2A receptordopamine type 2 receptor heteromerization

CN Hatcher-Solis - 2016 - search.proquest.com
D2-like receptors function presynaptically as autoreceptors on dopaminergic neurons and
postsynaptically on dopamine … antagonism whereby A2AR receptor stimulation inhibits D2R …

Receptor heteromers in Parkinson's disease and L-DOPA-induced dyskinesia

C Fiorentini, P Savoia, D Savoldi… - CNS & Neurological …, 2013 - ingentaconnect.com
… facilitation through excitation of D1R-expressing neuronsAdenosine A2A receptor-antagonist/dopamine
D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2

Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson's disease

MT Armentero, A Pinna, S Ferré, JL Lanciego… - Pharmacology & …, 2011 - Elsevier
… to form heteromers with A 2A adenosine receptors. Thus, the … of the caudate, putamen and
accumbens nuclei; (ii) output … of dopaminergic receptors will decrease the excitation of the …

A2A receptor and striatal cellular functions: Regulation of gene expression, currents, and synaptic transmission

SN Schiffmann, D Dassesse, P d'Alcantara, C Ledent… - Neurology, 2003 - AAN Enterprises
… activation reduced the amplitude of NMDA-mediated inward … knowledge, stimulation of this
cascade by A 2A receptors has … accumbens, whereas it is barely involved in the regulation of …

Key Modulatory Role of Presynaptic Adenosine A2A Receptors in Cortical Neurotransmission to the Striatal Direct Pathway

C Quiroz, R Luján, M Uchigashima… - The Scientific World …, 2009 - hindawi.com
Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens
neurons through A2A-D2 receptor heteromerization. Neuropsychopharmacology 34, 972…

Receptorreceptor interactions within receptor mosaics. Impact on neuropsychopharmacology

K Fuxe, D Marcellino, A Rivera, Z Diaz-Cabiale… - Brain research …, 2008 - Elsevier
… 2A /D 3 RM heteromers in the nucleus accumbens, may be found … ) by increasing EEG arousal
and thus probably attention. … D 2 /NMDA Co-IP, NMDA-mediated currents, behavioral data …

Increased desensitization of dopamine D2 receptor-mediated response in the ventral tegmental area in the absence of adenosine A2A receptors

R Al-Hasani, JD Foster, A Metaxas, C Ledent… - Neuroscience, 2011 - Elsevier
… Although GPCR heterodimerization tends to cause cross-… Dopamine neurons in the VTA
project to nucleus accumbensstimulation of dopamine neurons can activate D 2 receptors by …

A Systematic Review on Pharmacological Significance of Adenosine-2 A And Dopamine-D2 Receptor Interaction In Drug Addiction

SB Chander, G Debapriya - Journal of Innovation in …, 2017 - indianjournals.com
… decreases the expression of A2AD2 heteromers. Large numbers … mRNA in the nucleus
accumbens of human cocaine fatalities… Effects of adenosine A2A receptor stimulation on cocaine…

[HTML][HTML] … and bias through receptorreceptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization

K Fuxe, A Tarakanov, W Romero Fernandez… - Frontiers in …, 2014 - frontiersin.org
… interaction was missing in the nucleus accumbens in contrast to … receptor complexes like the
A2AD2–mGluR5 (94) and A2A… between adenosine A2A and dopamine D2 receptors. Anal …