The emerging role of dopamine–glutamate interaction and of the postsynaptic density in bipolar disorder pathophysiology: implications for treatment

A de Bartolomeis, EF Buonaguro… - Journal of …, 2014 - journals.sagepub.com
… -801 to NMDA receptors in nucleus accumbens and caudate-… receptor currents by D2 receptors
through adenosine A2a … More recently, it has been shown that stimulation of D1 receptors

CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling

F Meng, Z Guo, Y Hu, W Mai, Z Zhang, B Zhang, Q Ge… - Brain, 2019 - academic.oup.com
… , we assessed the loss of dopamine neurons by immunofluorescence staining of TH in the …
-stimulation or MPTP toxicity, suggesting an adenosine-dependent positive regulatory loop to …

Functional crosstalk between GPCRs: with or without oligomerization

L Prezeau, ML Rives, L Comps-Agrar, D Maurel… - Current opinion in …, 2010 - Elsevier
… , adenosine A2A, dopamine D2, and mGlu5 receptors have … (GPC), stimulation of the CaS
receptors by high extracellular … or parts of it, and the A2AD2 receptor heteromerization using

Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: effects on locomotor activity

LE Collins, DJ Galtieri, P Collins, SK Jones… - Behavioural brain …, 2010 - Elsevier
… or into the nucleus accumbens, as well as accumbensneurons may be a critical aspect of
the behavioral effects of drugs that act on these receptors, either because of heteromerization

Functional selectivity of allosteric interactions within G protein–coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer

X Guitart, G Navarro, E Moreno, H Yano, NS Cai… - Molecular …, 2014 - ASPET
… To control the cell number, sample protein concentration was … flash lamp, using a 10-nm
bandwidth excitation filter at 400-… several receptor heteromers, such as for D1R-histamine H 3 …

The promiscuous mGlu5 receptor–a range of partners for therapeutic possibilities?

MK Bird, AJ Lawrence - Trends in pharmacological sciences, 2009 - cell.com
receptor target for a particular disease state, using metabotropic glutamate receptor 5 (mGlu5) …
through which mGlu5 elicits physiological responses and (iii) possible methods to restrict …

Alcohol and caffeine: the perfect storm

S Ferré, MC O'Brien - Journal of caffeine research, 2011 - liebertpub.com
Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens
neurons through A2A-D2 receptor heteromerization. Neuropsychopharmacology. 2009;…

[引用][C] The roles of purinergic signaling in psychiatric disorders.

M Cieślak, J Czarnecka, K Roszek - Acta Biochimica Polonica, 2016 - ojs.ptbioch.edu.pl
… On GABAergic neurons D2 receptors coexpress with adenosine A2A … It is believed that the
attachment of adenosine to A1/D1 or A2A/D2 … -D2 receptors heteromerization and regulate

Two new adenosine receptor antagonists for the treatment of Parkinson's disease: istradefylline versus tozadenant

S Perez-Lloret, M Merello - Expert opinion on pharmacotherapy, 2014 - Taylor & Francis
Adenosine A2A receptors are localized in the brain, mainly within the caudate and putamen
nuclei of the basal ganglia. Their activation leads to stimulationA2A/A1 receptor heteromers

Extreme vetting of dopamine receptor oligomerization

WB Asher, S Mathiasen, MD Holsey… - … -Coupled Receptor …, 2017 - Springer
A2A-D2 heteromer that arginine residues in IL3 of D2 … of receptor heteromerization. Direct
epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors