Oxaliplatin: a review in the era of molecularly targeted therapy
T Alcindor, N Beauger - Current oncology, 2011 - mdpi.com
… Here, we review oxaliplatin from the pharmacologic and drug … were stratified according to
the results of liver function tests (… in adult cancer patients with impaired renal function. Clin …
the results of liver function tests (… in adult cancer patients with impaired renal function. Clin …
Organ Dysfunction Trials: Background, Historical Barriers, Progress in Overcoming Barriers, and Suggestions for Future Trials
S Kummar, SP Ivy, PJ Harris - Handbook of Anticancer Pharmacokinetics …, 2014 - Springer
… NCI organ dysfunction working group • … Although the FDA has traditionally encouraged
pharmacologically guided … Patients with impaired renal and hepatic function and cancer present a …
pharmacologically guided … Patients with impaired renal and hepatic function and cancer present a …
Risks and benefits of phase I liver dysfunction studies: should patients with severe liver dysfunction be included in these trials?
C Fountzilas, S Stuart, B Hernandez… - Investigational New …, 2017 - Springer
… In our patient population low serum albumin and liver function classification as … of hepatic
impairment. A SWOG early therapeutics committee and NCI organ dysfunction working group …
impairment. A SWOG early therapeutics committee and NCI organ dysfunction working group …
Phase I study of cediranib in combination with oxaliplatin and infusional 5-fluorouracil in patients with advanced colorectal cancer
E Chen, D Jonker, I Gauthier, M MacLean, J Wells… - … Cancer Research, 2009 - AACR
… Dose-escalating and pharmacologic study of oxaliplatin in adult cancer patients with
impaired hepatic function: a National Cancer Institute Organ Dysfunction Working Group …
impaired hepatic function: a National Cancer Institute Organ Dysfunction Working Group …
Predictive factors of oxaliplatin neurotoxicity: the involvement of the oxalate outcome pathway
L Gamelin, O Capitain, A Morel, A Dumont… - … Cancer Research, 2007 - AACR
… Dose-escalating and pharmacological study of oxaliplatin in adult cancer patients with
impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study. …
impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study. …
[HTML][HTML] Treatment options for metastatic colorectal cancer in patients with liver dysfunction due to malignancy
… very poor and alteration of liver function is … National Cancer Institute Organ Dysfunction
Working Group conducted a phase I study on the pharmacokinetics of oxaliplatin in patients …
Working Group conducted a phase I study on the pharmacokinetics of oxaliplatin in patients …
[HTML][HTML] Effect of renal dysfunction on toxicity in three decades of cancer therapy evaluation program–sponsored single-agent phase I studies
JH Beumer, F Ding, H Tawbi, Y Lin, D Viluh… - … of Clinical Oncology, 2016 - ncbi.nlm.nih.gov
… are often excluded because impaired renal function might be … this study, we show that
oncology organ dysfunction studies … of the drug or pharmacologically active metabolite or is a …
oncology organ dysfunction studies … of the drug or pharmacologically active metabolite or is a …
Chemotherapy in patients with organ dysfunction
JL Marshall, J Hwang, S Malik, A Amin - Oncology: An Evidence-Based …, 2006 - Springer
… The patient with a liver function study abnormality who received … Dose-escalating and
pharmacological study of oxaliplatin in … Cancer Institute Organ Dysfunction Working Group Study. J …
pharmacological study of oxaliplatin in … Cancer Institute Organ Dysfunction Working Group Study. J …
… and oxaliplatin (GEMOX) plus sorafenib, followed by sorafenib as maintenance therapy, for patients with advanced hepatocellular carcinoma: a preliminary study
Y Liu, H Yue, S Xu, F Wang, N Ma, K Li, L Qiao… - … of clinical oncology, 2015 - Springer
… Oxaliplatin at a dose … adult cancer patients with impaired hepatic function, and there was
no recommendation on dose reduction of single oxaliplatin for patients with hepatic dysfunction […
no recommendation on dose reduction of single oxaliplatin for patients with hepatic dysfunction […
[HTML][HTML] Clinical pharmacology of cancer therapies in older adults
A Hurria, SM Lichtman - British journal of cancer, 2008 - nature.com
… renal function in younger adults; however, it is a poor … , but a large impact of abnormal liver
function tests on docetaxel … A pharmacokinetic study of oxaliplatin in 25 patients between the …
function tests on docetaxel … A pharmacokinetic study of oxaliplatin in 25 patients between the …