… Since suramin has strong antitumor and anti-metastasis … The second type of two suramin
binding sites has a binding … -stranded DNA breaks through topoisomerase II poisoning. A …

… effects such as liver and kidney toxicity, mental disorders, etc. … santonin derivatives for
discovering novel therapeutic agents … (Eflornithine and Suramin) with EC 50 of antitrypanosomal …

… Most therapeutic agents have been developed empirically by … Suramin is a macromolecule
that binds to a number of … dispersion of epithelial cells (HT-29 colon cancer cells) induced …

… found to be more potent and less toxic than fumagillin [61,62,63,… Suramin has been
demonstrated to influence angiogenesis … treatment for patients with colorectal cancer and lung …

… Double screening of suramin derivatives on human colon cancer cells and on neural
cells provides new therapeutic agents with reduced toxicity. …

… Suramin failed to advance into clinical trials owing to its toxicity including adrenal insufficiency,
renal toxicity, … the design and optimization of heparanase inhibitors as therapeutic agents …

… adult brain and testis, and in human colon carcinoma cell lines [58]. Recently, suramin (1) has
… an anabolic effect in bone, suggesting this protein as a potentially useful therapeutic agent …

… of megazol with suramin or melarsoprol in the treatment of T. brucei … therapeutic agents,
as well as the control of parasite … aminothiadiazole in advanced colorectal cancer. An Illinois …

… the commonly used drugs used to treat the disease such as Suramin and … toxic in cancer
cells than the aglycone and 6 times less toxic in mice.[110] 18fluoro-2-deoxyglucose (FDG) has …

… provide … neuronal cells, from hepatocytes to adipose cells have further shown the exquisite
role of HuR in regulating many aspects of cellular differentiation and functions in various cell …