… for successful delivery of such central nervous system (CNS) acting … systematic approach
to study BBB, transport of drug across BBB by describing the mechanisms, factors, techniques…

… brain drug delivery, drug transport mechanism; different novel approaches used for drug
targeting to the brain and factors … a very important parameter for brain drug delivery as the BBB …

… In this review, we focus on nanoscale brain-targeting drug delivery strategies … brain derived
neurotrophic factor … The capacity to cross the BBB offers new ways for drug delivery to brain, …

… have shaped the current brain targeting research scenario. … factors that participate in the
transportation of various drug … , and non-invasive approaches to brain targeting have also been …

… represent a general and systematic method that can provide … General methods that can
enhance drug delivery to the brain … It is of remarkable simplicity and uses as parameters only the …

… in employing nanotechnology for drug delivery. The technological strategies are essentially
non-invasive methods of drug delivery to malignancies of the central nervous system (CNS) …

… saponins (by activation of Nrf2 antioxidant defense system). [ 13 ] These approaches could
improve the efficacy of drug delivery to the brain by NPs or NCs by restoring the BBB integrity. …

… Hence the factors that influence blood-brain distribution are … and invitro values demonstrated
that this in-vitro system is an … developments in drug delivery techniques provide reasonable …

… Citation 89 Techniques employing dendrimers are … of intranasal delivery is determined
by administration factors and … Citation 143,144 It is a dimensionless parameter. Real-time …

… Systemic toxicity remains the limiting factor for most methods that use intravascular …
Doubling the dose did not modify methotrexate pharmacokinetic parameters and resulted in a 2.3-…