… the recommendations for laboratory animal research of the … by the presence of more damaged
lung regions. However, this … in the absence of lung and blood volume change (41, 47, 49)…

… All animal studies were performed within guidelines for animal … by the known density of lung
parenchyma (1.050 g/mL −1 ). … higher lung inflation than was used in dogs in this study would…

… scan is necessary if lung density has changed between emission scans; (2) to evaluate the
linearity and reproduc ibility of our PET … effects of both plasma instillation and regional inflation…

… perimental animal study in a university research laboratory. … analyzed regional impedance
changes during lung inflation … the animals, and as the average lung density is about 0.5 g cm-…

… represent gas volume of the diffusion region of the lungs. In … density, n a , for a voxel containing
alveoli with mean volume … ex vivo study in dog lungs where we observed an increase in …

… blood volume. Furthermore, the bolus infusion technique does not saturate the PET scanner
with radioactivity accumulated in lung regions … In contrast, when sustained lung inflation was …

… by analyzing changes in regional lung density in PET … PET-derived regional data obtained
for control and 1, 2, and 4 h … PET cameras capable of measuring large regions of the lung, …

… water (rELW) using positron emission tomography (PET) and … [53] have argued that reduced
lung inflation made only an … a progressive increase in the lung density and blood volume, …

… , as in animal models (45). To minimize these causes of possible artifacts, we used … our
study because of regional differences in recruitment, distension and hyperinflation in ARDS lungs …

… inflation gradient at time points of prone positioning for 1, 2, and … quantitative information on
regional lung inflation and air … gradient of lung inflation in acute lung injury in a dog model in …