[HTML][HTML] The effect of atorvastatin on obsessive-compulsive symptoms of refractory obsessive-compulsive disorder (add-on therapy)

S Akouchekian, V Omranifard, P Moshfegh… - Advanced Biomedical …, 2018 - journals.lww.com
… guides, selective serotonin reuptake inhibitors (SSRIs) and … prefrontal cortex with potential
mechanisms of endothelial nitric oxide synthase. The results of this study suggest that statins

Atorvastatin evokes a serotonergic system-dependent antidepressant-like effect in mice

FK Ludka, LC Constantino, G Kuminek… - Pharmacology …, 2014 - Elsevier
… , po), a serotonin selective reuptake inhibitor (SSRI) was able to … frontal cortices' 5-HT content
when administered in the same … which statins can boost the SSRI antidepressant effect was …

Effects of statins on dopamine loss and prognosis in Parkinson's disease

SH Jeong, HS Lee, SJ Chung, HS Yoo, JH Jung… - Brain, 2021 - academic.oup.com
… total cholesterol level mediated the associations between statin use … to be associated with
cholesterol level, were entered as … statin increases striatal dopamine content without affecting …

[HTML][HTML] Update on statin treatment in patients with neuropsychiatric disorders

R Avan, A Sahebnasagh, J Hashemi, M Monajati… - Life, 2021 - mdpi.com
… administration of a selective serotonin reuptake-inhibitor (SSRI) [… association between
anxiety and non-adherence to statinsdopamine concentrations in the prefrontal cortex [114,115]. …

… in the expression of exon IIC transcripts of brain-derived neurotrophic factor gene by simvastain in chronic mild stress in mice: a possible link with dopaminergic …

DG Rana, AK Patel, CG Joshi… - Canadian Journal of …, 2014 - cdnsciencepub.com
… the possible interaction between dopaminergic agents and simvastatin in … Simvastatin
reverses the down regulation of dopamine D 1 and D 2 receptor expression in the prefrontal cortex

Statins and the brain: more than lipid lowering agents?

A Fracassi, M Marangoni, P Rosso… - Current …, 2019 - ingentaconnect.com
… indicates that the relationship between statins and PD is not … regions and by the release
of striatal dopamine [255]. Cruz … in the hippocampus and prefrontal cortex, two brain regions …

[HTML][HTML] The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

YM Vuu, A Kadar Shahib, M Rastegar - Pharmaceuticals, 2023 - mdpi.com
… , amongst its two groups, lipophilic statins have a higher ability … of simvastatin for 4 weeks in
SpragueDawley rats restored … significantly increased dopamine content in the striatum [168]…

HMG-CoA reductase inhibitor has protective effects against stroke events in stroke-prone spontaneously hypertensive rats

S Kawashima, T Yamashita, Y Miwa, M Ozaki… - Stroke, 2003 - Am Heart Assoc
… clarify the effect of a statin on stroke in stroke-prone spontaneously hypertensive rats (SHR-…
a clear relationship between the risk of stroke and serum cholesterol levels. However, recent …

Rosuvastatin improves olanzapine's effects on behavioral impairment and hippocampal, hepatic and metabolic damages in isolated reared male rats

A Mohammed, WM El-Bakly, A Ali… - Behavioural Brain …, 2020 - Elsevier
… such as serotonin (5-HT) and dopamine (DA), and dysfunction of these … In addition, statins
showed neuroprotective effects in … changes among all of the groups where: A and B, SR rats, …

[PDF][PDF] Statins—increasing or reducing the risk of Parkinson's disease?

AM Dolga, C Culmsee, L de Lau, Y Winter… - Experimental …, 2011 - academia.edu
effect with simvastatin on the dopamine content and reuptake. … decreased by 76% in the
prefrontal cortex after simvastatin … studies on the relation between statin use and the risk of PD …