Genome-wide association study identifies genetic risk factors for spastic cerebral palsy
AT Hale, O Akinnusotu, J He, J Wang, N Hibshman… - …, 2021 - journals.lww.com
… in the UK Biobank and FinnGen, we perform the first genome-wide association study (GWAS…
(de novo or inherited) with large effect sizes, as well as identifying copy number variations …
(de novo or inherited) with large effect sizes, as well as identifying copy number variations …
[HTML][HTML] Major depressive disorder: existing hypotheses about pathophysiological mechanisms and new genetic findings
… studies support the possible association between thyroid … cases and 176,486 controls from
UK Biobank, but the mood … of material deprivation, where the effect of depression-based PRS …
UK Biobank, but the mood … of material deprivation, where the effect of depression-based PRS …
[HTML][HTML] The impact of age on genetic risk for common diseases
… , skin cancer, atherosclerotic heart disease, hypothyroidism and calculus of gallbladder, …
UK Biobank, a prospective study of 500,000 people, we show that there is a tendency for genetic …
UK Biobank, a prospective study of 500,000 people, we show that there is a tendency for genetic …
Higher polygenic risk scores for anxiety disorders are associated with reduced area in the anterior cingulate gyrus
… -wide association study of anxiety disorders from the UK biobank (… in 34 bilateral brain regions
extracted using FreeSurfer. A … In this study, we investigated the effects of polygenic risk for …
extracted using FreeSurfer. A … In this study, we investigated the effects of polygenic risk for …
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways
… The meta-analysis of neuroticism comprised data from the UK Biobank study (UKB, full … Full
size image To investigate whether these genetic correlations reflected directional effects, we …
size image To investigate whether these genetic correlations reflected directional effects, we …
[HTML][HTML] Dump the “dimorphism”: Comprehensive synthesis of human brain studies reveals few male-female differences beyond size
L Eliot, A Ahmed, H Khan, J Patel - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
… regional cortical and subcortical volumes in males. But when structural and lateralization
differences are present independent of size… are largely based on brain size, and perform poorly …
differences are present independent of size… are largely based on brain size, and perform poorly …
Biological and clinical insights from genetics of insomnia symptoms
… UK Biobank (n=453,379) and confirm their impact on self-reported insomnia symptoms in the
HUNT study (… ), physician diagnosed insomnia in Partners Biobank (n=2,217 cases, 14,240 …
HUNT study (… ), physician diagnosed insomnia in Partners Biobank (n=2,217 cases, 14,240 …
[HTML][HTML] Investigating the relationship between depression and breast cancer: observational and genetic analyses
X Wu, W Zhang, X Zhao, L Zhang, M Xu, Y Hao, J Xiao… - BMC medicine, 2023 - Springer
… of the overall study design. We first used longitudinal follow-up data from the UK Biobank to
… To reduce biased estimate due to pleiotropic effects of genetic instruments, we adopted two …
… To reduce biased estimate due to pleiotropic effects of genetic instruments, we adopted two …
Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging
… We hypothesized that SNPs in the ABCC9 genomic region have an impact on gene … by
brain MRIs from living subjects. This study evaluated differences in brain volumes comparing …
brain MRIs from living subjects. This study evaluated differences in brain volumes comparing …
Sex differences in the associations of genetic, sociodemographic and cardiovascular risk factors with depression in the Canadian Longitudinal Study on Aging (CLSA)
E Théberge, J Dennis - medRxiv, 2023 - medrxiv.org
… of common genetic variants with small effect sizes contribute … The UK Biobank (UKB) is a
prospective health study of over … diabetes, hypothyroidism and/or a previous IHD diagnosis, …
prospective health study of over … diabetes, hypothyroidism and/or a previous IHD diagnosis, …