Artificial light at night, MRI-based measures of brain iron deposition and incidence of multiple mental disorders

J Jin, W Han, T Yang, Z Xu, J Zhang, R Cao… - Science of the Total …, 2023 - Elsevier
… This prospective study used data from the UK Biobank. ALAN was drawn from satellite …
our study reflects the impact of contextual light at night on health based on large sample size

Associations of six adiposity-related markers with incidence and mortality from 24 cancers—findings from the UK Biobank prospective cohort study

S Parra-Soto, ES Cowley, LFM Rezende, C Ferreccio… - BMC medicine, 2021 - Springer
… However, to minimise the effect of reverse causation in our study, we excluded all participants
with cancers diagnosed within the first 2 years of follow-up. Residual confounding is also …

Large-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults

L Yang, YN Ou, BS Wu, WS Liu, YT Deng… - Nature …, 2024 - nature.com
UK Biobank participants, we identified 162 unique genes in 35 IMDs, among which 124 were
novel genes. … protective effects on both autoimmune hypothyroidism (HPT) and psoriasis. …

Partitioning and aggregating cross-tissue and tissue-specific genetic effects to identify gene-trait associations

S Song, L Wang, L Hou, JS Liu - Nature Communications, 2024 - nature.com
… with independent studies. We apply MTWAS to 84 UK Biobank GWAS studies, which …
condition is likely to promote melanoma spread, which suggests the protective effect of thyroid

The relationship between brain structure volumes, depressive symptoms and body composition in obese/overweight and normal-/underweight women

L Łapińska, A Szum-Jakubowska, A Krentowska… - Scientific Reports, 2024 - nature.com
… which can pass through blood–brain barrier and impact brain structures 14 . … study from
United Kingdom Biobank analysed the relationship between fat distribution and brain volume. …

Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases

YY Liang, M Zhou, Y He, W Zhang, Q Wu… - Nature Human …, 2024 - nature.com
… , genetic and hospitalization data from the UK Biobank, the primary aim of the present study
… Despite observing potential effects of genetic confounders on hypothyroidism from EBI and …

Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach

TG Richardson, DJM Crouch, GM Power… - Nature …, 2022 - nature.com
size influences risk of asthma, eczema and hypothyroidism, although multivariable MR
suggested that these effects are mediated by body sizegenetic instruments from the UK Biobank

Machine Learning Approach with Harmonized Multinational Datasets for Enhanced Prediction of Hypothyroidism in Patients with Type 2 Diabetes

RP Adelson, A Garikipati, Y Zhou, M Ciobanu… - Diagnostics, 2024 - mdpi.com
… , possibly due to the stimulatory effect of nicotine on the metabolism [82]. Current smoking …
of Us Research Program. This research has been conducted using the UK Biobank Resource …

Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization study

L Zhang, K Li, Q Yang, Y Lin, C Geng, W Huang… - … of Medical Research, 2024 - Springer
… controls) were selected from the UK Biobank data, which was obtained from the … Thyroid
hormones may have non-genetic effects on the behavior of endothelial cells [17, 18]. In a study

Causal association between blood leukocyte counts and vascular dementia: a two-sample bidirectional Mendelian randomization study

S Liu, C Zhang, Y Zhang, Z Wu, P Wu, S Tian… - Scientific Reports, 2024 - nature.com
study, utilizing MR analysis with data from the UK Biobank … cognitive decline, decreased
brain volume, and more severe … potential impact of reverse causality on the study conclusions, …