Potential regulation mechanisms of P-gp in the blood-brain barrier in hypoxia

Y Ding, R Wang, J Zhang, A Zhao, H Lu… - Current …, 2019 - ingentaconnect.com
… -1-phosphate receptor 1 (S1P), vascular endothelial growth … may play an important role in
the down-regulation of P-gp activity. … differences in cell signaling and ligand specificity, rat and …

Emerging roles of the Angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking

D Pfaff, U Fiedler, HG Augustin - Journal of leukocyte biology, 2006 - academic.oup.com
… These include physical damage, hypoxia, increased shear … role of Eph receptors and
ephrin ligands in controlling the … to be an intrinsic property of arterial endothelial cells. Instead, …

Effects of thyroid hormone on tissue hypoxia: relevance to sepsis therapy

AI Lourbopoulos, IS Mourouzis, AG Trikas… - Journal of Clinical …, 2021 - mdpi.com
… vivo and in vitro via vascular endothelial growth factor A (VEGF… percentage of injured
mitochondria, and down-regulation of … Ligand-bound TRα on macrophages protected the kidney, …

Mitochondrial reactive oxygen species and risk of atherosclerosis

M Hulsmans, E Van Dooren, P Holvoet - Current atherosclerosis reports, 2012 - Springer
… role in the rapid down-regulation of eNOS mRNA levels [25]. In … ineffective against
hypoxic-ischemic injury in neonatal rats. … umbilical vein endothelial cells, vascular endothelial

Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin

A Hosseinzadeh, SA Javad-Moosavi, RJ Reiter… - Life sciences, 2018 - Elsevier
… Wnt/β‑catenin, vascular endothelial growth factor, platelet-derived … -induced lung injury through
down-regulation of oxidative … Wnt ligands pass signals inside the cell through the frizzled (…

Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders

H Qosa, DS Miller, P Pasinelli, D Trotti - Brain research, 2015 - Elsevier
… ET-1 from endothelial cells and activation of endothelin receptor-B (… ligands enhances release
of nuclear receptors from co-… /COX2 cascade to the down regulation of BCRP expression …

Role of liver sinusoidal endothelial cells in liver diseases

J Gracia-Sancho, E Caparrós… - Nature reviews …, 2021 - nature.com
… and other vascular endothelial cells. In the 1970s, the … -associated molecular patterns (DAMPs)
induced by cellular hypoxia. … used bosentan, an antagonist of endothelin receptors, and …

[PDF][PDF] The role of endogenous lung neuropeptides in regulation of the pulmonary circulation

IM Keith - Physiological Research, 2000 - researchgate.net
… can be regulated through hypoxic up- and down- regulation of … caveolae of the pulmonary
vascular endothelium. Most of AII's … TS: Enhanced endothelin-l and endothelin receptor gene …

Curcumin in inflammatory diseases

A Shehzad, G Rehman, YS Lee - Biofactors, 2013 - Wiley Online Library
cells including vascular endothelial cells, vascular smooth … pathways in a hypoxia-induced
cerebral edema model. … multiple sclerosis through the down-regulation of NF-κB, IL-6, IL-…

Epigenetic regulation of endothelial dysfunction and inflammation in pulmonary arterial hypertension

J Hudson, L Farkas - International journal of molecular sciences, 2021 - mdpi.com
… expressed eNOS gene in the vascular endothelium [33]. In … two classes of ligands that
are detected by host cells through a … Hypoxia signaling is mediated via the hypoxia-inducible …