Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins?
P Balakumar, S Kathuria, G Taneja, S Kalra… - … of molecular and cellular …, 2012 - Elsevier
… factor-α-induced down-regulation in eNOS protein expression … In addition, rosuvastatin
increased vascular endothelial nitric … beneficial effects on chronic hypoxia-induced pulmonary …
increased vascular endothelial nitric … beneficial effects on chronic hypoxia-induced pulmonary …
Endothelin ETB Receptor-Mediated Astrocytic Activation: Pathological Roles in Brain Disorders
Y Koyama - International journal of molecular sciences, 2021 - mdpi.com
… of peptides produced by the vascular endothelium [16], the … Among the endogenous ET
ligands, the ET A receptor shows … as hypoxia induce ET-1 production in brain microvascular …
ligands, the ET A receptor shows … as hypoxia induce ET-1 production in brain microvascular …
Improvement of vascular dysfunction by argirein through inhibiting endothelial cell apoptosis associated with ET-1/Nox4 signal pathway in diabetic rats
J Su, XR An, Q Li, XX Li, X Cong, M Xu - Scientific Reports, 2018 - nature.com
… that argirein could inhibit vascular endothelial cell apoptosis, which … Endothelin Receptor
Down-Regulation Mediated Ligand Regulation Mechanisms Protect Against Cellular Hypoxia …
Down-Regulation Mediated Ligand Regulation Mechanisms Protect Against Cellular Hypoxia …
Molecular mechanisms in endothelial regulation of cardiac function
L Kuruvilla, CC Kartha - Molecular and cellular biochemistry, 2003 - Springer
… tracting factors by vascular endothelial cells. Many of these … evidence that hypoxia is a potent
stimulus for endothelin-1 … of eNOS probably due to down regulation by TNF-α are found in …
stimulus for endothelin-1 … of eNOS probably due to down regulation by TNF-α are found in …
Inflammatory cytokines in vascular dysfunction and vascular disease
AH Sprague, RA Khalil - Biochemical pharmacology, 2009 - Elsevier
… one mechanism for the down-regulation of the cytokine cell … the expression of PDGF, vascular
endothelial cell growth factor (… ensuing placental ischemia/hypoxia may represent initiating …
endothelial cell growth factor (… ensuing placental ischemia/hypoxia may represent initiating …
Endothelial dysfunction, obesity and insulin resistance
D Prieto, C Contreras, A Sánchez - Current vascular …, 2014 - ingentaconnect.com
… flow in adipose tissue might further contribute to hypoxia and … Resistin directly induces
eNOS down-regulation and … inhibit cell cycle progression in human vascular endothelial cells. …
eNOS down-regulation and … inhibit cell cycle progression in human vascular endothelial cells. …
Vascular endothelial growth factor and angiogenesis
ANN Hoeben, B Landuyt, MS Highley, H Wildiers… - Pharmacological …, 2004 - ASPET
… 2-mediated ligand binding and subsequent receptor activation. … regulated by hypoxia in
cultured endothelial cells. … if posttranscriptional mechanisms participate in the regulation of …
cultured endothelial cells. … if posttranscriptional mechanisms participate in the regulation of …
Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
I Zachary - American Journal of Physiology-Cell Physiology, 2001 - journals.physiology.org
… Vascular endothelial growth factor (VEGF) ligands and … be upregulated in vascular smooth
muscle cells (VSMC) by hypoxia, … adhesion to the mesenteric endothelium in rats. VEGF was …
muscle cells (VSMC) by hypoxia, … adhesion to the mesenteric endothelium in rats. VEGF was …
Cellular and molecular basis of pulmonary arterial hypertension
… mice are protected against hypoxia-induced PH (16). … , ECM ligands, and actin-based
microfilaments inside the cell are … Verin AD "Regulation of vascular endothelial cell barrier function …
microfilaments inside the cell are … Verin AD "Regulation of vascular endothelial cell barrier function …
Endothelin@ 25–new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR R eview 12
JJ Maguire, AP Davenport - British journal of pharmacology, 2014 - Wiley Online Library
… ) subcommittee for the endothelin receptors, confirms the … tumours results in the down-regulation
of the receptor. As a result, … IUGR hypoxia rats is closely associated with the presence of …
of the receptor. As a result, … IUGR hypoxia rats is closely associated with the presence of …