… Notch signal receptor 1 (Notch1) and the Notch ligand Jag 1 (… effect of AS-IV against ischemia
and hypoxia injury may involve … Vascular endothelial cells are a barrier between circulating …

… abrogated by GW9662 or down-regulation of PPARγ. Taken … that regulate gene expression
in response to specific ligands, … When cells are stimulated by injury, hypoxia, microorganisms…

… , bosentan, and a selective endothelin receptor antagonist. Ang II … line with Ang II induces
secretion of TGFα, a ligand of the … , hypoxic damage correlates with increased activation of HIF-…

… Specific ligand recognition is mediated by a linear … LOX-1 expression is increased by hypoxia,
which is present in the … Therapeutic options include statins, AT 1 and endothelin receptor …

… of tissue hypoxia. In renal disease, incomplete recovery … the binding of ET1 ligand to endothelin
receptor type B on RECs [40]. ET… in monocrotaline-induced kidney injury in rats [52]. This …

… pathways, thus inhibiting the endothelin receptor type A/GSK-3β/… , resulting in down-regulation
of vascular endothelial (VE)-… focuses on describing the effects of GCS and hypoxia on VM. …

… of vascular endothelial cell growth factor (VEGF) production has also been documented [90].
C-ANP 4–23 inhibited VEGF production and endothelin (ET) or hypoxia-… Down regulation of …

… Apelin is localized in vascular endothelial cells while the … Also, no other endogenous ligands
for the APLNR are known, but … down-regulation of the APLNR in the arteries from hypoxic …

… phenotypically different from vascular endothelial cells. They … under hypoxia conditions, H19
exacerbates hypoxic stress of … Down-regulation of SIRT1 expression causes the contraction …

… , the vascular endothelium and renal tubular epithelial cells. … to hypoxic stress whereas ROS
mediate HIF-1 regulation through … Down-regulation of syndecan-1 in the ischemic glomeruli …