… endothelin receptors (ETR), including endothelin A receptors (ETaR) and endothelin B receptors
… vascular smooth muscles, and ETbRs on the surface of endothelial cells [7]. When ET-1 …

… In support of this view, one of the ETRB ligands, ET-1 is reported … in protection against
apoptosis by BQ788-mediated inhibition of … cells and that its down-regulation may participate in …

… , internalization of the endothelin receptor complex has been proposed as the mechanism
for down-regulation (78). After internalization, the ligand-receptor complex is thought to be …

… gel of an RNase protection experiment. RNase … The molecular mechanism of NOS III
down-regulation by … The glucocorticoid receptor is a ligand-activated transcription factor, but the …

… The exact mechanism of action is still part of numerous controversies. The … -mediated up-
or down-regulation of all genes was normalized to the control level or even inversely regulated …

… superfamily, and Fas ligand (FasL), triggers a pathway to cell … The mechanisms involved
down-regulation of Fas in tumor … and/or ET B receptors potentiates FasL-mediated apoptosis in …

… In contrast, PSS induced a transient down-regulation of miR-… Together with the results that
AP-1 mediates miR-21–induced … is expended to protect today’s children from lead exposure, …

… cells, we have developed the concept that vascular protection may be an important mode of
… and receptor activity were enhanced by endothelial adhesion to the α v β 3 ligand vitronectin …

… Among the endogenous ET ligands, the ET A receptor shows … have different regulatory
mechanisms, wherein the ET A type … underlie protection of the BBB by ET B receptor antagonism. …

… activation protects against development of endothelial dysfunction … for the exploitation of
GPBAR1 ligands in the treatment of … the role of PI3K/Akt in mediating down-regulation of ET-1 by …