… The molecular basis for heart failure is unknown, but oxidative … activity of xanthine
oxidoreductase (XOR)∗, a free-radical generating enzyme, increases in hypertrophied and failing …

… clinical outcome trials, particularly for congestive heart failure. Here we review XOR gene …
cardiovascular disease with an emphasis on heart failure. Xanthine oxidoreductase (XOR), first …

… In heart failure, XOR activity is upregulated as a consequence of its increased expression
induced by inflammatory cytokines, as well as of the augmented substrate supply, due to …

… is implicated in cardiac remodeling in heart failure (HF). As xanthine oxidoreductase (XOR) …
This increased expression translated into increased XOR activity in SHHF (54.9±4.1 mU/μg) …

… Oxidative stress due to purine degradation is associated with the development of chronic
heart failure (CHF). Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of purine …

… failure caused by ischemic heart disease or dilated cardiomyopathy were arrested in situ …
xanthine oxidoreductase activity, we subjected rat hearts (which display a relatively high activity…

… autopsy material were severe congenital heart defect and cardiopulmonary failure (1 case),
… levels were seen in the heart and the brain, and increased expression in the lung and kidney…

… Objective: Xanthine oxidase (XO) inhibitors enhance … whether this inotropic action is
preserved or magnified in failing rat … a markedly greater extent in preparations from failing hearts. …

… This is presumed due to extracardiac inhibition of xanthine oxidase, as studies [8, 9] … failed
to detect xanthine oxidoreductase (dehydrogenase plus oxidase) activity in the human heart. …

… In the failing heart, there is experimental evidence to suggest that xanthine oxidoreductase
(XOR), comprised of the isoenzymes XO and xanthine dehydrogenase (XDH), is an important …