… Enhanced expression and activity of xanthine oxidoreductase in the failing heart. J Mol Cell
… Regulation of endothelial cell xanthine dehydrogenase xanthine oxidase gene expression …

… are similar to those of heart failure and offer an additional potential … Xanthine oxidase (XO)
is important in purine metabolism, and its expression and activity are increased in heart failure …

… In the failing heart, there is experimental evidence to suggest that xanthine oxidoreductase
(XOR), comprised of the isoenzymes XO and xanthine dehydrogenase (XDH), is an important …

… We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable
effects on both ventricular and vascular performance in evolving heart failure (HF), thereby …

… of congestive heart failure (CHF). We examined whether inhibition of the superoxide anion
(·O 2 − )-generating enzyme xanthine oxidase (XO) with oxypurinol may improve cardiac …

… the increased activity of the enzyme xanthine oxidase (XO) with corresponding increased …
the recent evidence on XO as a novel and promising therapeutic target in heart failure. …

… diastolic heart failure in DS rats by causing reverse cardiac remodeling. Cardiac xanthine
oxidoreductase … Although the detailed mechanism of systolic heart failure has been extensively …

… For instance, patients with chronic heart failure due to dilated cardiomyopathy showed an
up-regulated expression of XOR, and the inhibition of enzyme activity by allopurinol …

… in heart failure. The principal sources of reactive oxygen species in the cardiomyocyte
are xanthine oxidoreductase (XOR), nicotinamide adenine dinucleotide phosphate oxidase (…

… In high-risk HF patients with reduced ejection fraction and elevated uric acid levels, xanthine
oxidase inhibition with allopurinol failed to improve clinical status, exercise capacity, quality …