Antioxidant defences in rat, pig, guinea pig, and human hearts: comparison with xanthine oxidoreductase activity

M Janssen, P van der Meer… - Cardiovascular …, 1993 - academic.oup.com
… the effect of xanthine oxidoreductase on ischaemiareperfusion … differences in xanthine
oxidoreductase activity in various … Explanted hearts of patients in end stage heart failure due to …

Acute effects of febuxostat, a nonpurine selective inhibitor of xanthine oxidase, in pacing induced heart failure

M Hou, Q Hu, Y Chen, L Zhao, J Zhang… - Journal of …, 2006 - journals.lww.com
xanthine oxidase inhibition with febuxostat enhances left ventricular (LV) function and
improves myocardial high energy phosphates (HEP) in dogs with pacing-induced heart failure (…

Regulation of endothelial cell xanthine dehydrogenase xanthine oxidase gene expression by oxygen tension

PM Hassoun, FS Yu, AL Shedd… - … of Physiology-Lung …, 1994 - journals.physiology.org
… that xanthine dehydrogenase/xanthine oxidase (XD/XO) activities of bovine endothelial cells
(EC) … transport, we failed to find stimulation of XD/XO activity or gene expression (results not …

Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium

JS McNally, A Saxena, H Cai, S Dikalov… - … , and vascular biology, 2005 - Am Heart Assoc
… (ROS) is xanthine oxidase (XO), an enzyme that uses xanthine and hypoxanthine as …
injury, endothelial dysfunction associated with congestive heart failure, atherosclerosis, and left …

Chronic xanthine oxidase inhibition following myocardial infarction in rabbits: effects of early versus delayed treatment

L Zhao, BM Roche, JL Wessale, A Kijtawornrat, JL Lolly… - Life Sciences, 2008 - Elsevier
Xanthine oxidase (XO) expression is increased in the failing heart, and animal studies in … )
function and myocardial oxygen efficiency in the failing heart. The purpose of this study was to …

Allopurinol, xanthine oxidase, and cardiac ischemia

BE Lee, AH Toledo, R Anaya-Prado… - Journal of …, 2009 - journals.sagepub.com
… on ischemic hearts as well as those with added chronic heart failure. Increased levels of …
dysfunctions are common characteristics experienced during cardiac ischemia and reperfusion (I…

Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress

J George, AD Struthers - Vascular health and risk management, 2009 - Taylor & Francis
… In dogs with pacing-induced heart failure, allopurinol improved myocardial contractility
and eff iciency in oxygen utilization, prevented increases in systemic vasoconstriction and …

Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice

Y Tanaka, T Nagoshi, A Yoshii, Y Oi… - Free Radical Biology …, 2021 - Elsevier
… the cardiac tissue UA level might increase in the failing heart … that cardiac tissue XDH activity
was significantly increased in … significantly reduced cardiac XDH activity (Supplementary Fig…

Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy

M Rajesh, P Mukhopadhyay, S Bátkai… - Journal of cellular …, 2009 - Wiley Online Library
… Note the enhanced expression of NADPH oxidase subunits in the diabetic mice, which is …
This coupled with the beneficial effects of ALP in various animal models of heart failure, also …

Increased plasma xanthine oxidoreductase activity deteriorates coronary artery spasm

K Watanabe, T Shishido, Y Otaki, T Watanabe… - Heart and Vessels, 2019 - Springer
Xanthine oxidoreductase (XOR) plays a pivotal role in producing both … activity and CAS
has not been elucidated. The aim of this study was to investigate whether plasma XOR activity is …