[HTML][HTML] Back to the future: lessons learned from the 1918 influenza pandemic

KR Short, K Kedzierska… - Frontiers in cellular and …, 2018 - frontiersin.org
… , elderly populations in remote settings, including Indigenous … in determining disease
outcome in the context of pandemic … mutations that increase human adaptation and/or virulence. …

Life course health development: an integrated framework for developing health, policy, and research

N Halfon, M Hochstein - The Milbank Quarterly, 2002 - Wiley Online Library
… environmental factors during the lifetime. This approach thus … a better understanding of how
diseases occur. By suggesting … development as a lifelong adaptive process thatbuilds and …

Ecology and mode-of-life explain lifespan variation in birds and mammals

K Healy, T Guillerme, S Finlay… - … of the Royal …, 2014 - royalsocietypublishing.org
… to determine whether our conclusions held when we excluded species with fewer than 100
longevity … can increase selection for molecular controls on senescence related diseases [11]. …

The good, the bad, and the ugly of ROS: new insights on aging and aging‐related diseases from eukaryotic and prokaryotic model organisms

AL Santos, S Sinha, AB Lindner - … and cellular longevity, 2018 - Wiley Online Library
… complex role in determining longevity than previously thought. … has been implicated as the
driving force in the aging process… Interventions targeting either of these two adaptive pathways …

On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations

A Qasim, M Turcotte, RJ De Souza… - Obesity …, 2018 - Wiley Online Library
… In extreme cases, obesity may reduce life expectancy by 6–14 … causes of the current obesity
epidemic, we will remain ill-… be categorized as adaptive or non-adaptive. Natural selection …

Climate variability and change in the United States: potential impacts on vector-and rodent-borne diseases.

DJ Gubler, P Reiter, KL Ebi, W Yap… - Environmental health …, 2001 - ehp.niehs.nih.gov
… worm parasites, spend part of their life cycle in a cold-blooded … The factors that determine
whether epidemic transmission will … diseases is the first step in addressing adaptive capacity. …

Senescent cells: SASPected drivers of age-related pathologies

Y Ovadya, V Krizhanovsky - Biogerontology, 2014 - Springer
Adaptive immune responses are severely affected by ageing … , and might play a role in
the pathogenesis of these diseases. … with increase in mice life-span. This study indicates that …

Bacterial plurality as a general mechanism driving persistence in chronic infections

GD Ehrlich, FZ Hu, K Shen, P Stoodley… - … and Related Research …, 2005 - journals.lww.com
… infections, but it is now recognized that the phenotype associated with these diseases
life cycle, 5,38 along with the understanding that horizontal gene transfer is the driving force in …

Metabolomics of human brain aging and age-related neurodegenerative diseases

M Jové, M Portero-Otín, A Naudí, I Ferrer… - … of Neuropathology & …, 2014 - academic.oup.com
… for the evolution of complex organisms that demand adaptive … is a major driving force in
determining the differential … operate throughout the life span and determine the rate of aging, …

Extreme lifespan of the human fish (Proteus anguinus): a challenge for ageing mechanisms

Y Voituron, M De Fraipont, J Issartel… - Biology …, 2011 - royalsocietypublishing.org
lifespans [5]. For centuries, many zoologists have been intrigued by the extremely long
lifespans … This aquatic salamander (25–30 cm) is the only cave-adapted vertebrate in Europe, …