… epidermal growth factor receptor (EGFR/ErbB1/HER1) belongs to the ErbB/HER-family of
tyrosine kinase receptors … -derivative able to bind and block the TK residues of EGFR, VEGFR2 …

… Studies of EGFR inhibitors in combination chemotherapy in front-line therapy of advanced
non–… In this study, an improvement in survival was obtained in the erlotinib arm: patients on …

… Therefore, specific EGFR inhibition is one of the key targets for cancer therapy. Two … EGFR
in cancer, different types of EGFR inhibitors, preclinical and clinical status of EGFR inhibitors …

… Even with the notable responses conferred by EGFR inhibitors … kinase activities of EGFR,
platelet-derived growth factor receptor, c-… to gefitinib therapy in epidermal growth factor receptor-…

… for the treatment of solid tumors are in development. The epidermal growth factor receptor
(EGFR) … In this context, a recent report has shown that treatment with quinazoline derivatives …

… Molecular biology of epidermal growth factor receptor inhibition for cancer therapy. …
Epidermal growth factor receptor inhibitors in the treatment of non-small-cell lung cancer. …

… should affect the clinical response to EGFR inhibition. To define the usefulness of KRAS
mutations as a predictor of response to anti-EGFR therapy, Lievre et al screened tumors from 30 …

… -derived cell lines (25). Augmented activity of membrane-associated tyrosine kinases, such
as EGFR, HER-2, and platelet-derived growth factor receptor… , treatment with EGFR inhibitors, …

… inhibitors are small molecules derived from … epidermal growth factor receptor inhibitors in
the treatment of metastatic colorectal cancer, and to define the contexts in which EGFR inhibitor …

… a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase
… related HER2/neu receptor. We show that PD153035 inhibits EGF-dependent EGF receptor …