Ertapenem pharmacokinetics and impact on intestinal microflora, in comparison to those of ceftriaxone, after multiple dosing in male and female volunteers

MWR Pletz, M Rau, J Bulitta, A De Roux… - Antimicrobial agents …, 2004 - Am Soc Microbiol
… Since ertapenem and … the pharmacokinetic profile of ertapenem, for which only limited
data are available, and to investigate its impact on the intestinal flora in comparison to those of …

In vitro Activity of Ertapenem against Common Clinical Isolates in Relation to Human Pharmacokinetics

I Friedland, LA Mixson, A Majumdar, M Motyl… - Journal of …, 2002 - Taylor & Francis
… , these pharmacodynamic principles were applied to human pharmacokinetic data following
administration of ertapenem, 1 g … of bacteria isolated from patients enrolled in the ertapenem

… and alternative β-lactams for the treatment of infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae: what impact on intestinal colonisation …

PL Woerther, R Lepeule, C Burdet… - International journal of …, 2018 - Elsevier
… the gut microbiota, especially the anaerobic bacteria and the … dosing regimen and
pharmacokinetic parameters is plausible. … treated with ertapenem, moxifloxacin or flomoxef, …

Pharmacokinetics and pharmacodynamics of ertapenem: an overview for clinicians

DE Nix, AK Majumdar… - Journal of Antimicrobial …, 2004 - academic.oup.com
… to alter the pharmacokinetics of ertapenem. Since the liver does not contribute to ertapenem
… hypoalbuminaemia) would impact on ertapenem pharmacokinetics in patients with hepatic …

Properties and potential of ertapenem

DM Livermore, AM Sefton… - Journal of Antimicrobial …, 2003 - academic.oup.com
… The antimicrobial spectrum and pharmacokinetics of ertapenem suggest several potential
… Some readers may think that ertapenem is tailor-made for purposes other than those for …

Intraabdominal tissue concentration of ertapenem

M Wittau, E Wagner, V Kaever, T Koal… - Journal of …, 2006 - academic.oup.com
Pharmacokinetics of ertapenem in healthy young adults support its use as a once-daily
antibiotic at a dose of 1 g intravenously (iv). Ertapenem is … spectrum, ertapenem seems to be an …

Pharmacokinetics of ertapenem in healthy young volunteers

AK Majumdar, DG Musson, KL Birk… - Antimicrobial agents …, 2002 - Am Soc Microbiol
… investigated the pharmacokinetics of total ertapenem in healthy … pharmacokinetic parameters
of total ertapenem were similar across the five studies. The mean CL P of total ertapenem

[HTML][HTML] Impact of broad-spectrum antimicrobial treatment on the ecology of intestinal flora

JJ Yang, JT Wang, A Cheng, YC Chuang… - Journal of microbiology …, 2018 - Elsevier
… We found that the patients who underwent the use of ertapenem had a significant lower …
Comparing the pharmacokinetics of the three antibiotics, ertapenem and moxifloxacin had a …

Acquisition of resistant bowel flora during a double-blind randomized clinical trial of ertapenem versus piperacillin-tazobactam therapy for intraabdominal infections

MJ DiNubile, JW Chow, V Satishchandran… - Antimicrobial agents …, 2005 - Am Soc Microbiol
… than in those treated with ertapenem. Treatment with antimicrobial agents broadly active
against enteric bacteria has the potential to select for bowel … In turn, bowel flora may provide an …

… faecalis, and Bacteroides fragilis in Monocultures and Mixed Cultures in an In Vitro Pharmacokinetic/Pharmacodynamic Model Simulating Concentrations in the …

S Schubert, A Dalhoff - Antimicrobial agents and chemotherapy, 2012 - Am Soc Microbiol
… The activities of moxifloxacin, imipenem, and ertapenem against pathogens causing severe
necrotizing pancreatitis were studied in an in vitro pharmacokinetics/pharmacodynamics (PK/…