[HTML][HTML] Significant sparse polygenic risk scores across 813 traits in UK Biobank
… 269,000 individuals of white British ancestry in UK Biobank, we systematically characterize
… Our transferability assessment of PRS models in UK Biobank revealed that the sparse PRS …
… Our transferability assessment of PRS models in UK Biobank revealed that the sparse PRS …
Repeat polymorphisms in non-coding DNA underlie top genetic risk loci for glaucoma and colorectal cancer
… To estimate haplotype-resolved VNTR allele lengths in UK Biobank participants, we applied
… VNTR+SNP haplotypes by analyzing short-read whole-genome sequencing (WGS) data …
… VNTR+SNP haplotypes by analyzing short-read whole-genome sequencing (WGS) data …
Whole genome association testing in 333,100 individuals across three biobanks identifies rare non-coding single variant and genomic aggregate associations with …
… We performed a multi-allele splitting procedure on each of the 60,648 pVCF whole genome
sequencing files provided by the UK Biobank using bcftools42 and then converted those …
sequencing files provided by the UK Biobank using bcftools42 and then converted those …
[HTML][HTML] The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians
YJ Kim, S Moon, MY Hwang, S Han, HM Jang… - Nature …, 2022 - nature.com
… UK Biobank that had become available in the interim. UK Biobank data from 337,475
European participants … and TC in our study and also replicated in UKB exome sequencing data, …
European participants … and TC in our study and also replicated in UKB exome sequencing data, …
[HTML][HTML] Genetic associations of protein-coding variants in venous thromboembolism
XY He, BS Wu, L Yang, Y Guo, YT Deng, ZY Li… - Nature …, 2024 - nature.com
… leveraged data from 349,038 UK Biobank (UKB) participants 20,21 and performed the WES
… exome sequencing data from 349,038 participants, we performed a WES analysis of VTE. …
… exome sequencing data from 349,038 participants, we performed a WES analysis of VTE. …
Multi-ancestry Whole-exome Sequencing Study of Alcohol Use Disorder in Two Cohorts
… This research used data from the UK Biobank (project ID: 41910), a population-based
sample of participants whose contributions we gratefully acknowledge. The data access is …
sample of participants whose contributions we gratefully acknowledge. The data access is …
Population scale whole genome sequencing provides novel insights into cardiometabolic health
… The whole genome sequencing (WGS) of UK Biobank participants is … UK Biobank
whole-exome sequencing processing 558 To quantify the gain from WGS vs WES in UK Biobank, we …
whole-exome sequencing processing 558 To quantify the gain from WGS vs WES in UK Biobank, we …
Polygenic architecture of rare coding variation across 400,000 exomes
… We analyzed publicly available UK Biobank exome sequencing association statistics from
Genebass for 22 complex traits and up to 394,783 individuals of European ancestry, including …
Genebass for 22 complex traits and up to 394,783 individuals of European ancestry, including …
[HTML][HTML] A loss-of-function CCR2 variant is associated with lower cardiovascular risk
… Among 428,191 unrelated (out of 454,775 with whole-exome sequencing data) UK
Biobank participants from the whole-exome sequencing data release, we found a total of 45 …
Biobank participants from the whole-exome sequencing data release, we found a total of 45 …
[HTML][HTML] The impact of rare protein coding genetic variation on adult cognitive function
…, H Ironfield, T Fang, Biogen Biobank Team… - Nature Genetics, 2023 - nature.com
… analyzed exome sequencing and genome-wide genotyping data from 454,787 UK Biobank
(UKB) participants … We show that adult cognitive function is strongly influenced by the exome-…
(UKB) participants … We show that adult cognitive function is strongly influenced by the exome-…