… of local administration of insulin-like growth factor-1 in addition to heavy slow resistance training in tendinopathic human patellar tendons: A randomized, double-blind …

JL Olesen, M Hansen… - … American journal of …, 2021 - journals.sagepub.com
… tenderness localized to the inferior pole of the patellar tendonexpression in the tendon to
the same extent as a tendon … of the tendon relative to the healthy region of the Achilles tendon. …

Tendon protein synthesis rate in classic Ehlers-Danlos patients can be stimulated with insulin-like growth factor-I

RH Nielsen, L Holm, JK Jensen… - Journal of applied …, 2014 - journals.physiology.org
… Thus our findings do not rule out that cEDS patients synthesize the same amount of tendon
… determine the long-term effects of this stimulus on tendon tissue. Also growth hormone (GH) …

Exercise-dependent IGF-I, IGFBPs, and type I collagen changes in human peritendinous connective tissue determined by microdialysis

JL Olesen, KM Heinemeier… - Journal of Applied …, 2007 - journals.physiology.org
… , Boston, MA) in an amount corresponding to an activity of 5.6 … synthesis around the human
Achilles tendon was observed in … insulin-like growth factor binding protein-4 expression and …

Interleukin-6: a growth factor stimulating collagen synthesis in human tendon

MB Andersen, J Pingel, M Kjær… - Journal of applied …, 2011 - journals.physiology.org
… This indicates that a relationship exists between the amount … tissue around the human
Achilles tendon will result in an … of type I collagen (ICTP), insulin-like growth factor 1 (IGF-1), and …

[HTML][HTML] In vitro and In vivo effects of IGF-1 delivery strategies on tendon healing: a review

I Miescher, J Rieber, M Calcagni… - International Journal of …, 2023 - mdpi.com
… of action, including insulin-like growth factor binding proteins. … co-localized with IGF-1 in
tendons [29]. Moreover, during … hand, expression levels of SOX9, a transcription factor essential …

[HTML][HTML] Insulin-like growth factor I (IGF-1) Ec/Mechano Growth factor–a splice variant of IGF-1 within the growth plate

W Schlegel, A Raimann, D Halbauer, D Scharmer… - PLoS …, 2013 - journals.plos.org
… MGF expression could be observed in the Achilles tendonsamount of Igf1 mRNA – a central
hormone for linear growth. … stabilizing structures and a nuclear localization signal as well as …

The roles of growth factors in tendon and ligament healing

T Molloy, Y Wang, GAC Murrell - Sports medicine, 2003 - Springer
tendon healing: insulin-like growth factor-I (IGF-I), transforming … of insulin-like growth factor-I
(IGF-I) mRNA expression (… blood and early repair cells due to its intra-articular location[56]). …

[HTML][HTML] Local biochemical and morphological differences in human Achilles tendinopathy: a case control study

L JO - BMC musculoskeletal disorders, 2012 - Springer
… hypothesize that growth factors like fibroblast growth factor (bFGF… with a long-term history of
chronic Achilles tendon pain (> 1/2 year… This supports our hypothesis that localized structural …

Local trauma in human patellar tendon leads to widespread changes in the tendon gene expression

KM Heinemeier, MP Lorentzen… - Journal of applied …, 2016 - journals.physiology.org
… in expression of insulin-like growth factor-I, connective tissue … treatment of Achilles tendon
rupture in adult humans can … In summary, it is evident that the localized trauma leads to an …

Clinical implications of growth factors in flexor tendon wound healing

C Hsu, J Chang - The Journal of hand surgery, 2004 - Elsevier
Insulin-like growth factor was discovered initially as “sulfation … after injury, primarily localized
to the more cellular epitenon. … multiple growth factors and to regulate their expression both …