Glycogen synthase kinase-3 as a key regulator of cognitive function

X Fan, Z Zhao, D Wang, J Xiao - Acta biochimica et biophysica …, 2020 - academic.oup.com
… the structure of GSK-3, the regulation of GSK-3 activity, and … of NMDA receptor-mediated
signaling by ketamine evoked … apparent that GSK-3 is a promising therapeutic target due to its …

Novel routes to bipolar disorder drug discovery

N Hoertel, P de Maricourt… - Expert opinion on drug …, 2013 - Taylor & Francis
… therapeutic targets of mood stabilizing drugs including: the glycogen synthase kinase-3 (GSK-3
Ketamine binding to NMDA receptor was found to increase extracellular glutamate levels …

[HTML][HTML] Preclinical models of treatment-resistant depression: challenges and perspectives

M Kolasa, A Faron-Górecka - Pharmacological Reports, 2023 - Springer
… The goal of the article is to contribute to better understanding and treatment of TRD, which
… kinase 3 (GSK-3) and AMPA receptors in the antidepressant effects of ketamine are also …

Depression and treatment response: dynamic interplay of signaling pathways and altered neural processes

V Duric, RS Duman - Cellular and molecular life sciences, 2013 - Springer
… main goal of the current depression research is to develop faster-… and enhances overall
memory and cognitive performance, … GSK-3 is one of the main regulators of neuronal survival, …

Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder

CA Zarate Jr, J Singh, HK Manji - Biological psychiatry, 2006 - Elsevier
… synthase kinase-3 (GSK-3, a direct target of lithium) and histone … -affinity NMDA antagonists
such as ketamine may have … the AMPA receptor potentiator LY451646 increased progenitor …

Ketamine in the past, present, and future: mechanisms, metabolites, and toxicity

ES Schwenk, B Pradhan, R Nalamasu, L Stolle… - Current pain and …, 2021 - Springer
… (AMPA) and the mammalian target of rapamycin by ketamine … combine ketamine with lithium
(which suppresses GSK 3 as … and should not obstruct the performance of important human …

Beyond monoamines-novel targets for treatment-resistant depression: a comprehensive review

JD Rosenblat, RS McIntyre, GS Alves… - Current …, 2015 - ingentaconnect.com
Increased synaptic glutamate levels and inhibition of NMDA by ketamine can lead to increased
influx of sodium via AMPA … kinase3 (GSK-3) leading to increased BDNF and potential anti…

A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases …

H Wesseling, H Rahmoune, M Tricklebank… - Journal of Proteome …, 2015 - ACS Publications
… aspartate (NMDA) receptor antagonist ketamine in psychiatric … ) were used to monitor key
performance parameters, such as … ), which is specifically involved in AMPA receptor trafficking. …

Ketamine use disorder: preclinical, clinical, and neuroimaging evidence to support proposed mechanisms of actions

L Vines, D Sotelo, A Johnson, E Dennis… - Intelligent …, 2022 - mednexus.org
… First, we aim to explain the structural and functional … receptor inhibition and subsequent
AMPA receptor activation, … and-post-operative performance were found among infant groups …

BDNF-GSK-3β-β-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats

LZ Xu, DF Xu, Y Han, LJ Liu, CY Sun… - International Journal …, 2017 - academic.oup.com
… GSK-3β is an important target of the therapeutic actions of … it may have affected other kinases
that regulated by PI3K/Akt … that the antidepressant-like effects of MOs might be mediated by …