… can undergo ectodomain shedding generating an 85 kDa … to the tumor cells inducing durable
and complete regressions in … ALCL and one with angioimmunoblastic T-cell lymphoma. All …

… strategies to overcome such drug resistance and metastasis … -231 cell line upon treatment
with one of TR compounds revealed the … For instance, T cell metabolism changes dynamically …

… Recent studies have revealed that MTHFD1/2 have been … a metabolic checkpoint determining
T cell differentiation. In Th17 … in various cancer types due to its role in generation of purine …

… γδ T-cell transformation, summarising the resulting γδ T-cell … , revealing non-redundant roles
of STAT5 homologs in fine-tuning γδ … inhibitors (methotrexate, pralatrexate), oral inhibitors of …

… below, recent discoveries have revealed unexpected new … use of methotrexate and
pralatrexate in these diseases. … This suggests that IDH2 mutations may cause an arrest in T-cell …

… gene therapy, based on an increase in the intensity of T cell … We revealed for the first
time that in lung fibroblasts the … , such as methotrexate and pralatrexate, are transported by …

… T-cell lymphoma PTCL NOS peripheral T-cell lymphoma, not … In rare cases, DLBCL shows
a tropism to CNS in forms of … deacetylase inhibitors, pralatrexate and monoclonal antibodies …

… anticancer drugs or antifolates are methotrexate, pralatrexate… anticancer efficacy is still not
revealed. Some examples of the … Also antitumor function of CD8+ T-cell is affected by changes …

… Our mechanistic research revealed that HDAC3 suppressed … Monoclonal cells cultured in
96-well plate were acquired by FACS … led to upregulated T-cell marker– and T-cell recruitment–…