Genome-wide linkage scan of quantitative traits representing symptom dimensions in multiplex schizophrenia families

S Ryu, HH Won, S Oh, JW Kim, T Park, EY Cho… - Psychiatry …, 2013 - Elsevier
… of disease-susceptibility genes, or separate traits related to disease-modifier genes. …
symptom dimensions of schizophrenia through genome-wide quantitative trait locus (QTL) linkage

Heritability of subcortical and limbic brain volume and shape in multiplex-multigenerational families with schizophrenia

DR Roalf, SN Vandekar, L Almasy, K Ruparel… - Biological …, 2015 - Elsevier
… use of multiplex-multigenerational families is likely to represent a … multiplex-multigenerational
families with schizophrenia. Such localized features may be related to distinct dimensions

Genetic contributions to transdiagnostic symptom dimensions in patients with major depressive disorder, bipolar disorder, and schizophrenia spectrum disorders

FS David, F Stein, TFM Andlauer, F Streit, SH Witt… - Schizophrenia …, 2023 - Elsevier
… Second, genome-wide association studies (GWAS) were … As demonstrated by twin and family
studies, each of the disorders has a … Bipolar multiplex families have an increased burden of …

The multidimensionality of schizotypy in nonpsychotic relatives of patients with schizophrenia and its applications in ordered subsets linkage analysis of schizophrenia

YJ Lien, HC Tsuang, A Chiang, CM Liu… - American Journal of …, 2010 - Wiley Online Library
… among the relatives from multiplex schizophrenia families. … Our previous genome-wide
linkage analysis reported that … be to conduct a quantitative trait locus (QTL) linkage analysis of …

A quantitative trait locus analysis of social responsiveness in multiplex autism families

JA Duvall, A Lu, RM Cantor, RD Todd… - American Journal of …, 2007 - Am Psychiatric Assoc
… Alzheimer’s disease and schizophrenia is about 0.45% and … genome-wide linkage scan for
social quantitative trait loci in … research represents the first genome scan of core social traits

A genomewide quantitative trait locus (QTL) linkage scan of NEO personality factors in Latino families segregating bipolar disorder

BD Lee, S Gonzalez, E Villa… - American Journal of …, 2017 - Wiley Online Library
… extended pedigrees originally ascertained for having multiplex cases of BP (963 cases of …
genome-wide suggestive cutoff (LOD scores >2.2) as determined for each triat are represented

[HTML][HTML] Genome-wide linkage analyses of quantitative and categorical autism subphenotypes

XQ Liu, AD Paterson, P Szatmari… - Biological …, 2008 - Elsevier
… In this study, using 976 multiplex families from the Autism … both ASD and schizophrenia, for
example, association of gene … to different dimensions, so the quantitative traits we used may …

Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q

T Paunio, A Tuulio-Henriksson… - Human molecular …, 2004 - academic.oup.com
… , we analyzed genome-wide data for 168 schizophrenia families … In the present study, we
investigated a set of quantitative trait … sets of 90 Irish multiplex schizophrenia families and follow-…

A genome-wide linkage scan for distinct subsets of schizophrenia characterized by age at onset and neurocognitive deficits

YJ Lien, PC Hsiao, CM Liu, SV Faraone, MT Tsuang… - PloS one, 2011 - journals.plos.org
… may reduce heterogeneity or represent the more direct effects of … of families of patients with
schizophrenia characterized by … sub-grouping by particular quantitative traits in these studies. …

Genome-wide association studies for common diseases and complex traits

JN Hirschhorn, MJ Daly - Nature reviews genetics, 2005 - nature.com
… common diseases and related quantitative traits. This strategy … The genome-wide association
approach therefore represents … , family-based and haplotype-based tests of association for …