An integrative functional genomics approach for discovering biomarkers in schizophrenia
… genome-wide association study (GWAS) are more likely to be associated with gene expression
quantitative trait loci … While SZ is believed to have a heritability of 80% based upon family …
quantitative trait loci … While SZ is believed to have a heritability of 80% based upon family …
Whole exome sequencing in dense families suggests genetic pleiotropy amongst Mendelian and complex neuropsychiatric syndromes
S Ganesh, A Vemula, S Bhattacharjee, K Mathew… - Scientific Reports, 2022 - nature.com
… These include common variant genome wide association … 60 family-controls without a lifetime
diagnosis of mental illness. … and familial SMI could represent a cumulative consequence of …
diagnosis of mental illness. … and familial SMI could represent a cumulative consequence of …
Factor analysis of lifetime psychopathology and its brain morphometric and genetic correlates in a transdiagnostic sample
… We identified genome-wide significant associations for MA … with one transdiagnostic psychosis
dimension and five specific … sample of SSD patients, relatives and healthy controls [72]. …
dimension and five specific … sample of SSD patients, relatives and healthy controls [72]. …
Genomewide association studies: history, rationale, and prospects for psychiatric disorders
Psychiatric GWAS Consortium … - American Journal of …, 2009 - Am Psychiatric Assoc
… factors in different families. Meta-analyses have supported … association in a combined
schizophrenia-bipolar data set. … M, Byerley W: A genome-wide search for genes predisposing to …
schizophrenia-bipolar data set. … M, Byerley W: A genome-wide search for genes predisposing to …
Exome sequence data from multigenerational families implicate AMPA receptor trafficking in neurocognitive impairment and schizophrenia risk
… We searched for susceptibility loci at a quantitative trait locus (QTL) … implicated in linkage
and genome-wide association studies, … of the genetic loads carried by our multiplex families. …
and genome-wide association studies, … of the genetic loads carried by our multiplex families. …
Can genomics help usher schizophrenia into the age of RDoC and DSM-6?
AH Fanous - Schizophrenia Bulletin, 2015 - academic.oup.com
… of BPD in biological relatives of schizophrenia probands and … represents the commonly
accepted facets of schizophrenia … SNPs with genome-wide significant association to finer-grained …
accepted facets of schizophrenia … SNPs with genome-wide significant association to finer-grained …
[PDF][PDF] A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11
MN Ogdie, IL Macphie, SL Minassian, M Yang… - The American Journal of …, 2003 - cell.com
… a genomewide linkage scan in 204 nuclear families comprising … presence of six or more
symptoms on dimensions of inattention, … linkage scan in 270 ASPs represents the largest linkage …
symptoms on dimensions of inattention, … linkage scan in 270 ASPs represents the largest linkage …
[图书][B] Quantitative Genetic Methods to Dissect Heterogeneity in Complex Traits
TB Bigdeli - 2012 - search.proquest.com
… levels consistent with genome-wide association significance, … -based approach to family-based
association, R3HDML and … 2.404), an implementation of the quantitative trait PDT with …
association, R3HDML and … 2.404), an implementation of the quantitative trait PDT with …
Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction
F Guan, T Ni, W Zhu, LK Williams, LB Cui, M Li… - Molecular …, 2022 - nature.com
… genome-wide association study, MHC the major histocompatibility complex, cQTL chromatin
quantitative trait … , and HCN families) involved in schizophrenia pathophysiology are reliable …
quantitative trait … , and HCN families) involved in schizophrenia pathophysiology are reliable …
Chromosome 1 loci in Finnish schizophrenia families
… evidence for linkage both in the multiplex families collected from … 1 previously identified by
our two genome-wide scans (2,3). … Of these nuclear families, 136 had been represented in the …
our two genome-wide scans (2,3). … Of these nuclear families, 136 had been represented in the …