Genome-wide DNA methylation analysis of articular chondrocytes identifies TRAF1, CTGF, and CX3CL1 genes as hypomethylated in osteoarthritis

L Zhao, Q Wang, C Zhang, C Huang - Clinical Rheumatology, 2017 - Springer
… identify osteoarthritis (OA)-associated differentially methylatedgenome-wide methylation
profiling [13,14,15] has revealed … a role in the cartilage and bone destruction. Although CTGF is …

Identification of differentially methylated regions in new genes associated with knee osteoarthritis

CA Bonin, EA Lewallen, S Baheti, EW Bradley… - Gene, 2016 - Elsevier
… a genome-wide assessment of differentially methylated sites (DMSs) and … Our study revealed
the utility of a systematic DMR search as an alternative … Bone remodelling in osteoarthritis

[HTML][HTML] Enrichment of genomic pathways based on differential DNA methylation profiles associated with knee osteoarthritis pain

S Montesino-Goicolea, L Meng, A Rani, Z Huo… - Neurobiology of Pain, 2022 - Elsevier
… IPA revealed that pain-related DMRs were enriched across … was to identify differentially
methylated CpG regions and their … , maintenance, and repair of bone, cartilage, and other soft …

[HTML][HTML] Use of integrative epigenetic and mRNA expression analyses to identify significantly changed genes and functional pathways in osteoarthritic cartilage

A He, Y Ning, Y Wen, Y Cai, K Xu, J Han… - Bone & joint …, 2018 - boneandjoint.org.uk
… , and 26 pathways were detected for osteoarthritis. It has been … differentially methylated
genes, including 678 methylated … controls for genome-wide DNA methylation profiling. This …

[HTML][HTML] Decoding the regulatory landscape of ageing in musculoskeletal engineered tissues using genome-wide DNA methylation and RNASeq

MJ Peffers, K Goljanek-Whysall, J Collins, Y Fang… - PLoS …, 2016 - journals.plos.org
… repair and osteoarthritis (reviewed [1]), bone fracture … diseases such as osteoarthritis,
osteoporosis and tendinopathy. … that were affected by the differentially methylated genes, we used …

Candidate methylated genes in osteoarthritis explored by bioinformatics analysis

J Liu, Y Hao, Y Wang, S Hu, K Xu, C Lu - The Knee, 2016 - Elsevier
Genome-wide methylation screening has identified 1214 differentially methylated genes (DMGs…
Furthermore, roles of GnRH have been proven to be closely associated with bone tissue …

Epigenome‐wide association of DNA methylation in whole blood with bone mineral density

JA Morris, PC Tsai, R Joehanes, J Zheng… - Journal of Bone and …, 2017 - academic.oup.com
Genomewide association studies (GWAS) of BMD directly … for quantifying BMD and
diagnosing osteoporosis, have been … of more than 200 differentially methylated CpGs; however, to …

Analysis of gene expression and methylation datasets identified ADAMTS9, FKBP5, and PFKBF3 as biomarkers for osteoarthritis

ZF Li, RQ Zhang, XL Yang, DD Zhang… - Journal of cellular …, 2019 - Wiley Online Library
… and conducted a genome-wide methylation analysis to explore … effects on bone by human
bone mesenchymal stem cells (… assume that the differential methylation sites in ADAMTS9 is …

Genome-Wide DNA Methylation Profile Analysis Identified Runx2 and CSGALNACT1 Involved in the Development of Osteonecrosis of the Femoral Head

AW He, L Liu, Y Ning, Y Wen, P Li, B Cheng, S Cheng… - 2019 - papers.ssrn.com
… by the death of bone cells and bone marrow, which 61 … of 106 FLS to scan differently methylated
genes between … B, tuberculosis, and other osteoarthritis and autoimmune diseases were …

[HTML][HTML] Osteoarthritis year in review: genetics, genomics, epigenetics

A Ratneswaran, M Kapoor - Osteoarthritis and cartilage, 2021 - Elsevier
… ) scans, identified eight bone area variants associated with hip or … showed robust genome-wide
significance between a DNA … was published, revealing subpopulations of chondrocytes …