Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag

T Winkler, X Fan, J Cooper, R Desmond… - Blood, The Journal …, 2019 - ashpublications.org
growth factors, especially granulocyte colony-stimulating … the monosomy 7 clone, suggesting
the transformed monosomy … may be preferentially stimulated by EPAG to proliferate. One …

Neutropenia–More Genetic Defects Than Ever Expected

K Welte - Primary Immunodeficiency Disorders, 2014 - Elsevier
… human granulocyte-macrophage colony-stimulating factor (… more cellular genetic abnormalities,
for example monosomy 7, … to a preferential secondary outgrowth of a pre-existing cell

[HTML][HTML] Cytogenetic features in myelodysplastic syndromes

D Haase - Annals of hematology, 2008 - Springer
… ago [47]. … granulocyte colony-stimulating factor (G-CSF), as well as Schwachman’s
syndrome. It is of special interest that myeloid cells harboring monosomy 7 seem to be preferentially

[HTML][HTML] Aplastic anemia: pathophysiology and treatment

NS Young, A Bacigalupo, JCW Marsh - Biology of Blood and Marrow …, 2010 - Elsevier
… of monosomy 7, in AA, as also in congenital neutropenia, elevated granulocyte-colony
stimulating factor (G-… , favors cells bearing a G-CSF receptor that signals for proliferation and not …

Aplastic anemia

NS Young, P Scheinberg… - Current opinion in …, 2008 - journals.lww.com
Monosomy 7 has been linked to exogenous use of granulocyte-colony stimulating factor (G-…
of a short G-CSF receptor isoform, which signals proliferation but not differentiation [40] . The …

A Non–ATP-Competitive Dual Inhibitor of JAK2V617F and BCR-ABLT315I Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive …

SS Jatiani, SC Cosenza, MVR Reddy, JH Ha… - Genes & …, 2010 - journals.sagepub.com
Monosomy 7 cells show increases in a differentiation-… (e) ON044580 inhibits growth of
cells expressing imatinib-… preferentially express the truncated class IV G-CSF receptor, which …

Jak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies

SS Jatiani, SJ Baker, LR Silverman… - Genes & …, 2010 - journals.sagepub.com
… MDS patients that arises due to aberrant cytokine receptor signaling. Monosomy 7 cells show
… This compound blocks JAK/STAT signaling, inhibits proliferation, and induces apoptosis in …

[HTML][HTML] Altered expression of CSF3R splice variants impacts signal response and is associated with SRSF2 mutations

A Lance, LJ Druhan, CG Vestal, NM Steuerwald… - Leukemia, 2020 - nature.com
… the receptor for granulocyte-colony stimulating factor (G-CSF), … overall G-CSF stimulated
proliferation is determined by the … the granulocyte colony-stimulating factor receptor orchestrate …

Alternatively Spliced CSF3R in Human Health and Disease

BA Wang - 2022 - scholarscompass.vcu.edu
… Elevated alternative colony stimulating factor 3 receptor (CSF3R) isoforms, called classes, …
to preferentially stimulate the proliferation of monosomy 7 cells bearing the Class IV isoform

[PDF][PDF] Bortezomib Induces Granulocytic Differentiation of CD34 Cells from Congenital Neutropenia Patients by Reversing Hyperactivate-STAT5a-Dependent …

K Gupta, I Kusnetsova, O Klimenkova, M Klimiankou… - Blood, 2014 - Citeseer
… role in granulocyte colony-stimulating factor receptor (G-CSFR)… 2,4 . The phosphorylation of
these tyrosine kinases leads to … a preferential secondary outgrowth of pre-existing cell clones …