Intranasal delivery of a nicotine vaccine candidate induces antibodies in mouse blood and lung mucosal secretions that specifically neutralize nicotine
… improving the immunogenicity of nicotine vaccine candidates … that MPL can be used safely
to induce strong specific mucosal … as a nicotine hapten carrier and MPL as an adjuvant to test …
to induce strong specific mucosal … as a nicotine hapten carrier and MPL as an adjuvant to test …
Enhancing immunogenicity of a 3′ aminomethylnicotine-DT-conjugate anti-nicotine vaccine with CpG adjuvant in mice and non-human primates
MJ McCluskie, DC Pryde, DP Gervais, DR Stead… - International …, 2013 - Elsevier
… anti-nicotine vaccines that utilize nicotine-derived haptens … , especially when a delivery system
such as an aluminum salt is … candidate vaccines not just on ability to induce high antibody …
such as an aluminum salt is … candidate vaccines not just on ability to induce high antibody …
Rationalization of a nanoparticle-based nicotine nanovaccine as an effective next-generation nicotine vaccine: A focus on hapten localization
… a significantly higher immunogenicity against nicotine and a … Brain and serum samples
were collected 3 min post nicotine … It should be pointed out that no molecular adjuvants were …
were collected 3 min post nicotine … It should be pointed out that no molecular adjuvants were …
[HTML][HTML] Recent trends in vaccine delivery systems: a review
CH Saroja, PK Lakshmi… - International journal of …, 2011 - ncbi.nlm.nih.gov
… safety profile of live vaccines, weak immunogenicity of sub-… over vaccines prepared with
conventional adjuvants. In vivo … to be higher in mice receiving intradermal vaccination than IM …
conventional adjuvants. In vivo … to be higher in mice receiving intradermal vaccination than IM …
Nanoparticle-based nicotine vaccine
PO Ilyinskii, LPM Johnston - … to treat substance use disorders: Vaccines …, 2016 - Springer
… immunogenic and do not elicit the undesired responses (vector effect); and (4) nanoparticles
may act as an intracellular depot of antigen and adjuvant to … adjuvants may solve this safety …
may act as an intracellular depot of antigen and adjuvant to … adjuvants may solve this safety …
Recent advances in vaccine delivery
J Soni Khyati, P Patel Rakesh… - Journal of Applied …, 2011 - japsonline.com
… Intradermal delivery includes delivery of vaccine to the dermis or epidermis for enhancement
of immunogenicity… involves the application of vaccine antigen and often adjuvant to the skin …
of immunogenicity… involves the application of vaccine antigen and often adjuvant to the skin …
Engineering of a hybrid nanoparticle-based nicotine nanovaccine as a next-generation immunotherapeutic strategy against nicotine addiction: A focus on hapten …
… adjuvants to form particulate antigens, conjugate nicotine … (NP)-based nicotine vaccine to
improve the immunogenicity of the conjugate … Assessment of the safety of nicotine vaccines. (A) …
improve the immunogenicity of the conjugate … Assessment of the safety of nicotine vaccines. (A) …
Transcutaneous and intradermal vaccination
B Combadiere, C Liard - Human vaccines, 2011 - Taylor & Francis
… , classic vaccination techniques using a needle present safety … some vaccine preparations
use TLRs agonists as adjuvants, to … hepatitis B vaccine: a comparison of immunogenicity in …
use TLRs agonists as adjuvants, to … hepatitis B vaccine: a comparison of immunogenicity in …
Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice
DC Pryde, LH Jones, DP Gervais, DR Stead… - PloS one, 2013 - journals.plos.org
… function could in theory be achieved with vaccines that induce even higher antibody titers
and/… to be “immunogenic” but in our experience, are largely influenced by adjuvants, whereas …
and/… to be “immunogenic” but in our experience, are largely influenced by adjuvants, whereas …