Transcutaneous immunization with heat-labile enterotoxin: development of a needle-free vaccine patch

GM Glenn, DC Flyer, LR Ellingsworth… - … review of vaccines, 2007 - Taylor & Francis
Adjuvants and antigens delivered into the skin can result in … receiving the 1.5-µg dose
intradermal alone (20,142 ELISA units). … This remarkable safety and immunogenicity has led to the …

[HTML][HTML] Key roles of adjuvants in modern vaccines

SG Reed, MT Orr, CB Fox - Nature medicine, 2013 - nature.com
… , their formulation aspects and safety considerations, and … far require relatively high doses
owing to their weak immunogenicity, which … Thus, CpG may be a good adjuvant for intradermal

Vaccine Delivery Systems

TL Bowersock, S Narishetty - Biodrug Delivery Systems, 2016 - taylorfrancis.com
… However, subunit vaccines need potent adjuvants to be … plants were as immunogenic as
those produced in other expression … Low dose intradermal vaccination is superior to high dose …

Molecular attributes of conjugate antigen influence function of antibodies induced by anti-nicotine vaccine in mice and non-human primates

MJ McCluskie, J Thorn, PR Mehelic, P Kolhe… - International …, 2015 - Elsevier
… Herein we have evaluated immunogenicity in mice of 27 lots … (OH) 3 ] were selected as
adjuvants since we have previously … Ab of higher titer and higher avidity is hypothesized as being …

[HTML][HTML] Nanotechnology and vaccine development

MG Kim, JY Park, Y Shon, G Kim, G Shim… - Asian Journal of …, 2014 - Elsevier
safety profile over traditional vaccine, these vaccines suffer … , insufficient adjuvant activity
may result in limited immunogenicity. … The intradermal administration of GLA within oil-in-water …

Immunopharmacotherapy for nicotine addiction

JW Lockner, KD Janda - 2013 - books.rsc.org
nicotine vaccine candidates first seek to evaluate the safety … subjects verified the vaccine's
immunogenicity and tolerability… adjuvants, we are optimistic about the prospects for nicotine

Conventional and nontraditional delivery methods and routes of vaccine administration

RA Diotti, V Caputo, GA Sautto - Practical Aspects of Vaccine Development, 2022 - Elsevier
… , due to the administration of these vaccines either subcutaneously or intradermally [10]. …
immunogenicity of this delivery system could be explained by the possible adjuvant activity …

[HTML][HTML] Classification of laser vaccine adjuvants

S Kashiwagi, T Brauns… - … of vaccines & vaccination, 2016 - ncbi.nlm.nih.gov
vaccine [24], an inactivated influenza vaccine [24], a nicotine … is safe and effective in enhancing
the drug delivery through the … vaccine immunogenicity by enabling intradermal delivery of …

Laser vaccine adjuvant for cutaneous immunization

X Chen, MX Wu - Expert review of vaccines, 2011 - Taylor & Francis
… were intradermally injected with indicated adjuvants with or … Likewise, when a nicotine
vaccine was mixed with MPL at a 1… significance for increasing vaccine immunogenicity in the …

Improving immunogenicity and safety of flagellin as vaccine carrier by high-density display on virus-like particle surface

Y Zhao, Z Li, X Zhu, Y Cao, X Chen - Biomaterials, 2020 - Elsevier
adjuvant, or intradermally immunized with 3 μg KLH-Nic or left non-immunized. Adjuvants
were simply mixed with vaccines before delivery … in our nicotine vaccine development studies. …