Efficacy of generic meropenem products in combination with colistin in carbapenemase-producing Klebsiella pneumoniae experimental osteomyelitis

P Tattevin, A Dinh, I Ghout, W Mouton… - International journal of …, 2020 - Elsevier
… relevant carbapenemases encountered in Enterobacterales … Concentrations were
measured by high-performance liquid … tandem mass spectrometry (LC-MS/MS) after protein …

Phenotypic detection of ESBL and MBL producing Klebsiella pneumoniae in critically ill patients with nosocomial pneumonia

MM Khalifa, MA ELmokhtar, SH Ahmed… - Microbes and …, 2024 - mid.journals.ekb.eg
… , carbapenem resistance has arisen in K. pneumoniae, which is aided by the synthesis of K.
… According to the World Health Organization, Klebsiella pneumoniae is one of the top three …

Detection of antimicrobial resistance (AMR) and antimicrobial susceptibility testing (AST) using advanced spectroscopic techniques: A review

M Ramzan, A Raza, Z un Nisa… - TrAC Trends in …, 2024 - Elsevier
… strains and 20 Enterobacterales isolates. Polymerase chain … LC-MS/MS can detect all
known AMR genes at the molecular … aureus, an ultra-high performance liquid chromatography-…

Sulfamoyl heteroarylcarboxylic acids as promising metallo-β-lactamase inhibitors for controlling bacterial carbapenem resistance

J Wachino, W Jin, K Kimura, H Kurosaki, A Sato… - Mbio, 2020 - Am Soc Microbiol
… is one approach to restore carbapenem efficacy in carbapenem-… coli and dually NDM-1/VIM-1-producing
Klebsiella pneumoniae … and the supernatants subjected to LC-MS/MS analysis. …

[HTML][HTML] Estimation of the Difference in Colistin Plasma Levels in Critically Ill Patients with Favorable or Unfavorable Clinical Outcomes

J Sanabria, V Garzón, T Pacheco, MP Avila, JC Garcia… - Pharmaceutics, 2021 - mdpi.com
… was more common to find Klebsiella pneumoniae (Table 1). … and the percentage of
carbapenemase detection for some of … Some of the Klebsiella pneumoniae isolates had bla KPC …

Phenotypic and genetic screening of Klebsiella pneumoniae isolates from human UTI patients for beta-lactamases and their genetic diversity analysis by ERIC and …

S Bobbadi, MN Bobby, BK Chinnam, PN Reddy… - Brazilian Journal of …, 2023 - Springer
… to Carbapenem … mediated Klebsiella pneumoniae carbapenemase (KPC) and rarely by
chromosomally mediated elements. Prevalence of Carbapenem resistant Klebsiella pneumoniae

Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-β-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding

YH Yan, TT Zhang, R Li, SY Wang, LL Wei… - Journal of Medicinal …, 2023 - ACS Publications
… Notably, in the case of Klebsiella pneumoniae KP18–29 expressing NDM-1, the … The
compound concentrations in plasma were determined using LC-MS/MS. The compound plasma …

The Role of Mass Spectrometry in the Discovery of Antibiotics and Bacterial Resistance Mechanisms: Proteomics and Metabolomics Approaches

M Cuevas-Cruz, U Hernández-Guzmán… - Current Medicinal …, 2023 - ingentaconnect.com
… [37] and the detection of bacterial enzymes such as carbapenemases which target … of
LC-MS/MS quantitative proteomics has positioned this technology as a commonly used technique

Prevalence and Characteristics of Ertapenem-Resistant Klebsiella pneumoniae Isolates in a Taiwanese University Hospital

JJ Wu, LR Wang, YF Liu, HM Chen… - Microbial Drug …, 2011 - liebertpub.com
… /mass spectrometry (LC-MS/MS) using an Ultimate Nano high-performance liquid chromatography
system (LC … Impermeability may play a role in carbapenem resistance in our ETP-R K. …

Metabolomics revealed mechanism for the synergistic effect of sulbactam, polymyxin-B and amikacin combination against Acinetobacter baumannii

S Zhu, J Yue, X Wang, J Zhang, M Yu, Y Zhan… - Frontiers in …, 2023 - frontiersin.org
… a previously reported method with modifications (Zhu et al., 2022c). Samples were analyzed
by LC–MS equipped with an Ultimate 3,000 ultra-highperformance liquid chromatography (…