… and structural characterization of histone modifying enzymes … respective catalytic
mechanisms, substrate specificities, and … these enzymes, highlighting studies of the histone …

… These interactions likely provide a large degree of binding energy, but would be expected
to exhibit a low degree of enzyme specificity. The lysine side chain and the isopropionyl linker …

… histone modifications is due to the combined effects of targeting histone modifying enzymes
to specific loci, as well as to the inherent substrate specificity of the enzymes themselves. In …

… For this reason, HKMTs should not be classified by sequence homology, but instead on the
basis of epigenetic criteria regarding their histone specificity (Table 2). At this point it is not …

… vitro specificity of PCAF/GCN5 for acetylation of histone H3 on Lys14, the point of attachment
to CoA. An X-ray crystal structure … role of loop dynamics in the catalytic mechanism 62,63 . …

… bound to their respective histone substrates. Finally, we … specificity of histone-modifying
enzymes within the context of their regulatory functions in chromatin structure and modification. …

… in the cytoplasm or those forming nucleosomes as a result of their differing substrate
specificities. For example, the GNC5-related N-acetyltransferase (GNAT) family (GCN5/p300-…

… In common with many histone-modifying enzymes, the type-A … enzyme recruitment, activity
and substrate specificity. For … dysregulated function of histone modifying enzymes can be …

… This Review focuses on histone demethylases, their reaction mechanisms, substrate specificity,
their role in transcriptional regulation and the molecular mechanisms through which their …

… is shared between HDAC8 and APAH, substrate specificity is markedly different. The dimer
… strictly conserved to enforce substrate specificity: crystal structures of the inactive H143A and …