[PDF][PDF] How Tat targets TAR: structure of the BIV peptide–RNA complex
NL Greenbaum - Structure, 1996 - cell.com
… Two new NMR structures describing the complex formed by a peptide from the BlV Tat
protein with the TAR RNA provide a significant advance in our understanding of the ways in …
protein with the TAR RNA provide a significant advance in our understanding of the ways in …
Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex
JD Puglisi, L Chen, S Blanchard, AD Frankel - Science, 1995 - science.org
… ) binds to its target RNA, TAR, and activates transcription. A 14-… ) structure of an RNApeptide
complex that shows how the major groove of the BIV TAR site is recognized by the BIV Tat …
complex that shows how the major groove of the BIV TAR site is recognized by the BIV Tat …
[HTML][HTML] Structure-based design of a dimeric RNA–peptide complex
DM Campisi, V Calabro, AD Frankel - The EMBO Journal, 2001 - embopress.org
… cases it also may be desirable to target specific RNA elements involved in … BIV and HIV
Tat–TAR complexes also shows how two RNA sites that are virtually superimposable in structure …
Tat–TAR complexes also shows how two RNA sites that are virtually superimposable in structure …
TAR RNA Recognition by a Cyclic Peptidomimetic of Tat Protein,
… the structure of the complex of the cyclic peptide bound to BIV … and peptide structures) of the
core peptide/RNA interaction region … Obviously, our target is the HIV Tat−TAR interaction, but …
core peptide/RNA interaction region … Obviously, our target is the HIV Tat−TAR interaction, but …
Structural mimicry of retroviral tat proteins by constrained β-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements
Z Athanassiou, RLA Dias, K Moehle… - Journal of the …, 2004 - ACS Publications
… of a backbone cyclic peptide that targets BIV TAR RNA was reported. In this work, we show
… The BIV2 and BIV5 peptide−RNA complexes were studied by 1 H NMR spectroscopy in …
… The BIV2 and BIV5 peptide−RNA complexes were studied by 1 H NMR spectroscopy in …
Binding of a cyclic BIV β-tat peptide with its TAR RNA construct
JBH Tok, RC Des Jean, J Fenker - Bioorganic & medicinal chemistry letters, 2001 - Elsevier
… structures to adopt diverse yet complex tertiary structures has … resulting cyclopeptide to
the TAR RNA target, observed by … suggest that in certain cases of peptide–RNA interactions, …
the TAR RNA target, observed by … suggest that in certain cases of peptide–RNA interactions, …
Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein
A Davidson, TC Leeper… - Proceedings of the …, 2009 - National Acad Sciences
… The NMR structure of a peptide–RNA complex reveals that … The Tat-TAR complex is an
attractive target for developing … structures between BIV and HIV Tat and TAR, we reasoned …
attractive target for developing … structures between BIV and HIV Tat and TAR, we reasoned …
Design of RNA-targeting macrocyclic peptides
MJ Walker, G Varani - Methods in Enzymology, 2019 - Elsevier
… Structure determination of peptide-RNA complexes produce atomic resolution … to target it
with our BIV-TAR mimetics even if this interaction is distinct from the TAR-Tat interactions in that …
with our BIV-TAR mimetics even if this interaction is distinct from the TAR-Tat interactions in that …
Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein
A Davidson, K Patora-Komisarska… - Nucleic acids …, 2011 - academic.oup.com
… in our original model system of BIV Tat/TAR ( 21 ). Ile14 is … The Tat–TAR interaction has long
been considered a target for … observed in the structure of a lead peptide-RNA complex ( 23 ). …
been considered a target for … observed in the structure of a lead peptide-RNA complex ( 23 ). …
[HTML][HTML] Structure-based design of RNA-binding peptides
MJ Walker, G Varani - Methods in enzymology, 2019 - ncbi.nlm.nih.gov
… Structure determination of peptide-RNA complexes produce atomic resolution … to target it
with our BIV-TAR mimetics even if this interaction is distinct from the TAR-Tat interactions in that …
with our BIV-TAR mimetics even if this interaction is distinct from the TAR-Tat interactions in that …