… and broad usage of amitriptyline for the management of chronic neuropathic pain in South
… tailoring treatment and thereby improving amitriptyline efficacy in these patients. To test this …

… of CYP2D6 genotype on the beneficial and adverse effects of … the extremes regarding drug
effectiveness and response who … high risk for side effects in amitriptyline therapy. Clin. Chem. …

… been used for treatment of chronic pain (amitriptyline, duloxetine, … applied towards improving
drug efficacy, shortening the time … efficacy and the side effect profile of oxycodone; CYP2D6 …

… the plasma concentrations, efficacy and adverse effects of the major … The CYP2D6 system
has been extensively studied and is the … gene and the effect of amitriptyline may be postulated. …

… incidence of side effects and treatment effects with amitriptyline and … Thus, CYP2D6 genotypes
have been removed from … We questioned whether the increased therapeutic efficacy of C …

… dosing of codeine based on CYP2D6 genotypes. It is suggested … the efficacy of treatment
and reduce the adverse effects, … co-analgesics include amitriptyline, desipramine, imipramine, …

… ), antidepressants (such as amitriptyline, clomipramine or … of CYP2D6 may also play a
role in the efficacy of tramadol. … in additive effects or synergism and may improve efficacy at …

… and CYP2D6 genotypes and amitriptyline pharmacokinetics … in the amitriptyline analgesic
efficacy in CYP2D6 NMs by … effects in patients with diabetic peripheral neuropathy with …

… The efficacy of drugs for neuropathic pain has been established in … The combination of
amitriptyline and fluphenazine was not … among healthy volunteers and/or on pilot studies among …

… drug effects exaggerated responses or lack of effectiveness of … of central nervous system and
peripheral nerve endings23. … recent pilot study, the relationship between CYP2D6 genotype…