Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists

A Anand, DS Charney, DA Oren… - Archives of general …, 2000 - jamanetwork.com
N-METHYL-D-aspartate (NMDA) receptor dysfunction has been … of new medications
for the treatment of schizophrenia. … The therapeutic use of NMDA and α-amino-3-hydroxy-5-…

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

RJ Harvey, BK Yee - Nature reviews Drug discovery, 2013 - nature.com
… mediated by NMDA (N-methyl-D-aspartate) receptors at … The search for alternative
therapeutic routes has centred on … These drugs include dopamine D 2 receptor antagonists that …

Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism

IL Petrakis, D Limoncelli… - American Journal of …, 2004 - Am Psychiatric Assoc
… ethanol dependence whether response to the NMDA receptor … Antagonists of the N-methyl-d-aspartate
(NMDA) receptor … Prior to the administration of any study medication, subjects …

Effects of γ-aminobutyric acid agonists andn-methyl-d-aspartate antagonists on a multiple schedule of ethanol and saccharin self-administration in rats

KL Shelton, RL Balster - … of Pharmacology and Experimental Therapeutics, 1997 - ASPET
… Clearly, pharmacologically useful treatment drugs for ethanol abuse should … on a self-administration
base line, such as bottle drinking and simple operant … NMDA N-methyl-d-aspartate

An update on NMDA antagonists in depression

B Pochwat, G Nowak, B Szewczyk - Expert review of …, 2019 - Taylor & Francis
… Thus, the search for better acting agents is a continuous process. One of the primary targets
… of new antidepressant drugs is the glutamate N-methyl-D-aspartate (NMDA) receptor. …

The recognition and management of protracted alcohol withdrawal may improve and modulate the pharmacological treatment of alcohol use disorder

F Caputo, M Cibin, A Loche… - Journal of …, 2020 - journals.sagepub.com
… (GABA) and N-methyl-d-aspartate (NMDA) systems, naltrexone, … medications in order to
control PAW (NMDA antagonists and GABA agonists) rather than to immediately reduce alcohol

Motor impairment produced by ethanol and site-selective NMDA receptor antagonists in mice: tolerance and cross-tolerance

ON Neznanova, EA Blokhina, IA Sukhotina… - Alcohol, 2000 - Elsevier
use of N-methyl-d-aspartate (NMDA) receptor antagonists infer acute and repeated administration
schedules for management of … of the NMDA receptor antagonist-based medications. …

Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization

CG Parsons, W Danysz, G Quack, S Hartmann… - … of Pharmacology and …, 1997 - ASPET
… modulatory site of the N-methyl-d-aspartate (NMDA) receptor (… glycine dependence of the
Merz glycine B antagonists were … NMDA by at least 75% of their depression by the antagonists

The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications

JM Loftis, A Janowsky - Pharmacology & therapeutics, 2003 - Elsevier
… and synthesis of conantokin (Con)-R, an NMDA receptor peptide antagonist from the venom
of Conus rediatus, was performed. With the use of well-defined animal seizure models, Con-…

Use of acamprosate and opioid antagonists in the treatment of alcohol dependence: a European perspective

M Soyka, J Chick - The American journal on addictions, 2003 - Wiley Online Library
… Its action at N-methyl-D-aspartate (NMDA) receptors appears … pharmacological agents in
the treatment of addiction.The only … In search of a new pharmacological treatment for drug and …