… -resistant and -sensitive MM cell lines, overcomes the survival … as examining perifosine
in combination with bortezomib in … the antimyeloma effects of bortezomib and melphalan[93,95]. …

… This article describes emerging antimyeloma agents in mid-stage … that perifosine has cytotoxic
activity against MM cell lines, 64 … doses of bortezomib, lenalidomide, or perifosine.70, 71 …

… multiple myeloma cell lines in the absence and in the presence of bone marrow stromal …
experiments, cells were cultured with dexamethasone, bortezomib, perifosine, and Revlimid, in …

… bioavailability, in MM cell lines and patient MM cells and define its … as novel or emerging
(lenalidomide, perifosine, bortezomib, … agents led to a significantly increased apoptosis and cell …

… against lenalidomide- and bortezomib-resistant cell lines and … in vitro synergy with a number
of other anti-myeloma agents … bortezomib are structurally dissimilar, and influence different …

… the newly emergent antimyeloma agents and will describe … in both primary MM cells and
all MM cell lines. Soluble CS1 is … that perifosine enhances the cytotoxic effects of bortezomib, …

… -κB activation in MM cell lines and primary tumor cells from MM patients. Importantly… novel
agents targeting MM cells in the BM milieu, such as thalidomide, lenalidomide, and bortezomib…

… of single-agent panobinostat demonstrated modest antimyeloma activity in … and bortezomib
by promoting apoptosis [22]. A phase I study with perifosine in combination with lenalidomide …

… most highly in primary myeloma cells and cell lines, and is not … ) and novel (bortezomib,
lenalidomide, Akt inhibitor perifosine, … as well as experimental antimyeloma drugs. HuLuc63-…

… Prior use of lenalidomide and bortezomib was a prerequisite for eligibility in this … and novel
anti-myeloma agents. Recently, a phase I/II study of perifosine in combination with bortezomib …