… to have activity in bortezomib-resistant cell lines. Carfilzomib … In a phase 1 study of
perifosine/bortezomib/dexamethasone … direct the selection of antimyeloma therapeutic agents. …

… Some responses were also seen to perifosine, which … active antimyeloma drugs. The day 0
(filled) and day 14 (pink … the toxicity associated with bortezomib, which is more in line with the …

… action of bortezomib and other antimyeloma agents can result … of lenalidomide, bortezomib
and dexamethasone (RVD). … as an antimyeloma agent in terms of activity, toxicity and …

… of novel agents such as thalidomide, lenalidomide, or … combination of dasatinib + bortezomib
+ dexamethasone (Da–B–… conventional anti-myeloma agents on myeloma cell lines and in …

… Bortezomib induces Hsp27 expression in cell lines in vitro; … that the combination of perifosine
and bortezomib yields synergistic … Antimyeloma activity of heat shock protein-90 inhibition. …

… , BG45, bortezomib and HDAC3 knockdown in MM cell lines were … perifosine, and that
combined therapy with bortezomib and … Antimyeloma activity of a multitargeted kinase inhibitor, …

… bortezomib induces apoptosis in these leukemia cell lines, we … Furthermore, novel Akt
inhibitors such as perifosine, have … cells and further showed that bortezomib is a feasible agent to …

… in common myeloma cell lines as well as primary myeloma cells at … bortezomib, thalidomide
and lenalidomide, multiple myeloma … When common anti-myeloma drugs like melphalan or …

… and chemo-resistant MM cell lines, with half maximal inhibitory … lenalidomide and bortezomib
enhances tumour cytotoxicity … of perifosine (KRX-0401) in combination with lenalidomide …

… and highly specific inhibitor of PDK1, induces potent cytotoxicity in MM cell lines including …
vitro cytotoxic effects of antimyeloma agents such as melphalan, etoposide, or bortezomib [17]. …